Understanding how older adults' muscles recover from injury
Muscle Phenotyping in Frail Older Patients Having Hip Surgery Following Fracture
University of Nottingham · NCT04764617
This study looks at how frail older adults recover their muscle strength and health after a hip fracture to see what might help them heal better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | University of Nottingham (other) |
| Locations | 1 site (Nottingham) |
| Trial ID | NCT04764617 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the functioning of muscles in frail older adults, particularly those who have sustained a hip fracture from a fall. It aims to assess not only muscle strength but also the composition of muscle cells, including fats and proteins, and the expression of genes related to muscle function. By understanding these factors, the study seeks to identify the underlying vulnerabilities that contribute to poor recovery outcomes in this population. The findings could inform future interventions aimed at improving muscle health and recovery in older adults.
Who should consider this trial
Good fit: Ideal candidates for this study are older adults with a Clinical Frailty Score of 4 or higher who have sustained a hip fracture from a fall and require surgical intervention.
Not a fit: Patients who have sustained their hip fracture from high-impact trauma or have chronic conditions causing muscle wasting may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery strategies for older adults with frailty, potentially reducing complications and dependency after hip fractures.
How similar studies have performed: While this study explores specific cellular functions in frail older adults, similar research on sarcopenia and muscle recovery has shown promising results, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical Frailty Score (assessed as part of standard care) ≥ 4 * Fractured hip, sustained following a fall, that requires surgery * Good understanding of spoken and written English language * Able to give informed consent, or availability of a legally acceptable surrogate to provide consent Exclusion Criteria: * Those who fell and sustained their hip fracture greater than 12 hours prior to hospitalisation. * Those who have fallen and sustained a hip fracture whilst an in-patient in hospital * Those who sustained the hip fracture as a result of high impact trauma (e.g. road traffic accident) * Surgery carried out later than 96 hrs after fall * Chronic neurological, inflammatory or musculoskeletal disorders which result in muscle wasting, e.g. Multiple sclerosis, muscular dystrophy, rheumatoid arthritis * Any co-morbidity which precludes hip surgery * Those with a compromised swallowing reflex which would prevent the participant from taking fluids orally, will be excluded. * Those taking diabetes medication
Where this trial is running
Nottingham
- Queens Medical Centre; Department of Orthopaedics — Nottingham, United Kingdom (RECRUITING)
Study contacts
- Principal investigator: Ben Ollivere, MBBS — University of Nottingham
- Study coordinator: Adeel Ikram, BMBS
- Email: msxai10@exmail.nottingham.ac.uk
- Phone: +44 (0) 115 823 1115
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Frailty Syndrome