Understanding how low oxygen levels affect oesophagogastric cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients with oesophagogastric adenocarcinoma to investigate the metabolic responses triggered by hypoxia, or low oxygen levels, in tumors. It aims to analyze how these hypoxic conditions contribute to the aggressiveness and treatment resistance of the cancer. Patients will be administered pimonidazole hydrochloride to assess the extent of hypoxia in their tumors, which may reveal important insights into their prognosis and potential treatment options. The study seeks to improve understanding of the relationship between tumor hypoxia and cancer outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and females aged 18-90 years.
* Patients with biopsy proven oesophageal or gastric adenocarcinoma who are undergoing either surgical resection or staging laparoscopy.

Exclusion Criteria:

* Non-adenocarcinoma cancer (e.g. oesophageal squamous cell carcinoma)
* Antibiotic therapy within the last 8 weeks
* Previous oesophageal and gastric resection
* Allergy to pimonidazole
* Unable or unwilling to provide informed written consent
* Pregnant women

Where it's running

• Imperial College NHS Healthcare Trust
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: George Hanna — Imperial College London
• Study coordinator: Henry Douglas Robb, MBChB BSc (Hons) MSc MRCS
• Email: henry.robb19@imperial.ac.uk
• Phone: +44 (0) 207 594 8847

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.