Understanding how inflammation affects smell in chronic rhinosinusitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the mechanisms behind olfactory dysfunction in patients with chronic rhinosinusitis with nasal polyps. It will assess whether type 2 inflammation impacts the regeneration of the olfactory epithelium and if a treatment targeting T2 inflammatory cytokines can influence olfactory dysfunction. Participants will undergo olfactory testing and nasal brushing before and after a 3-month treatment period to evaluate changes in their sense of smell. The study focuses on understanding the relationship between inflammation and olfactory recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks.
* Endoscopic visualisation of bilateral sinonasal polyps
* SSI (TDI) \< 30.75 and decreased sense of smell subjectively
* Eosinophilia \> 300/μl of blood Ku/l
* On a stable nasal steroid treatment for at least 4 weeks

Exclusion Criteria:

* Active smoking
* Primary and secondary immune deficiencies
* Ciliary diseases (cystic fibrosis, primary ciliary diskinesia)
* History of or current nasal malignancies
* \< 18 years and \> 70 years
* Patients unable to express consent
* Use of systemic corticosteroids for \< 4 weeks before visit 1 • Use of systemic or local antibiotics for \< 4 weeks before visit 1

Where it's running

• Cliniques Universitaires Saint-Luc
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Valérie Hox, MD, PhD — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
• Study coordinator: Valérie Hox, MD, PhD
• Email: valerie.hox@saintluc.uclouvain.be
• Phone: +3227648675

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis with Nasal Polyps

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• Tezepelumab in real-world CRSwNP: a real-world look at patient outcomes

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• BBT002 in healthy adults and in people with chronic rhinosinusitis with nasal polyps

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  Recruiting at 12 sites Phase 1/2 Bambusa Therapeutics · Beijing, Beijing Municipality and 11 other locations · NCT07436949

• Real-world use of tezepelumab for chronic rhinosinusitis with nasal polyps in Russia

  This study will see how tezepelumab works in adults in Russia who have chronic rhinosinusitis with nasal polyps, with or without asthma.

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• Joint pulmonologist and ENT consult for asthma with nasal polyps care

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• Real-time detection of eosinophilic nasal polyps using high-sensitivity spectroscopy

  This will test a non-invasive light-based device that shines a safe light into the nose to quickly find eosinophilic nasal polyps in adults with chronic rhinosinusitis with nasal polyps.

  Recruiting The Affiliated Hospital of Qingdao University · Qingdao, Shandong · NCT07125586

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.