Understanding how HIV treatment affects gut bacteria

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the impact of antiretroviral therapy (ART) on the gut microbiome in individuals with HIV. By collecting stool samples from participants before and after switching their ART regimen, researchers hope to gain insights into how different antiretroviral drugs influence gut health. The findings could lead to more personalized treatment options based on individual gut microbiome profiles. This research is crucial as gut health is linked to overall well-being and can affect various health conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥18 years.
* Willing to undergo stool sample collection on two occasions.
* Able to give written, informed consent.
* Have evidence of HIV infection
* Have been on stable antiretroviral treatment for the previous ≥12months.
* Planning to switch ART regimen from one class of drugs or delivery method to another.

Exclusion Criteria:

* HIV viral load \>50 copies/ml blood

Where it's running

• Manchester University NHS Foundation Trust
  Manchester, Greater Manchester, United Kingdom Recruiting

Study contacts

• Study coordinator: Gabriella LA Lindergard, PhD
• Email: gabriella.lindergard@manchester.ac.uk
• Phone: +447855212958

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.