Understanding how gut bacteria affect blood sugar after weight loss surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the role of gut microbiota in the changes in glycemic response following bariatric surgery. By analyzing the microbiome before and after procedures such as sleeve gastrectomy and gastric bypass, the researchers hope to uncover the mechanisms that lead to metabolic improvements. The findings could identify new targets for pharmacological interventions, potentially reducing the need for surgical options. The study addresses previous methodological limitations in microbiome research related to bariatric surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* candidates of bariatric surgery or cholecystectomy
* age 18-70
* male/female

Exclusion Criteria:

* previous bariatric surgery
* type 1 diabetes
* antibiotic treatment 3 months prior to the study
* probiotic treatment 3 months prior to the study
* chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
* any pathologic findings during endoscopy
* participants who will suffer from a post-operation complication

Where it's running

• Weizmann Institute of Science
  Rehovot, Israel Recruiting
• Souraski medical center
  Tel Aviv, Israel Recruiting

Study contacts

• Principal investigator: Danit Dayan, MD — Souraski medical center
• Study coordinator: Avner Leshem, MD
• Email: avner.leshem@weizmann.ac.il
• Phone: +972547487555

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• 15-year outcomes after sleeve gastrectomy in France

  This study looks at how people who had sleeve gastrectomy have fared over 15 years to see long-term weight changes and health effects.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT07883018

• Mother and baby health after bariatric surgery in pregnancy

  This study follows pregnant women who have had bariatric surgery and those who have not to see how nutrition, pregnancy health, and baby outcomes compare.

  Recruiting at 3 sites Helse Nord-Trøndelag HF · Ålesund, Møre og Romsdal and 2 other locations · NCT07877233

• Understanding glucagon and sugar metabolism after meals in people with and without PBH after weight-loss surgery

  This study tests how glucagon and post-meal glucose handling differ between people who have post-bariatric surgery hypoglycemia and those who don’t.

  Recruiting at 2 sites Phase 4 Joslin Diabetes Center · Birmingham, Alabama and 1 other locations · NCT07818707

• Collagen Supplements After Sleeve Gastrectomy

  This observational study looks to see if taking collagen-containing supplements after sleeve gastrectomy affects muscle mass, body composition, and body image in adults who had bariatric surgery.

  Recruiting Mudanya University · Bursa, Yıldırım · NCT07809152

• Postoperative nausea, vomiting and pain after bariatric surgery in Sweden

  This study looks at how often people have nausea, vomiting, and pain after bariatric surgery in Sweden and whether anesthesia type or regional blocks affect those outcomes.

  Recruiting at 2 sites Umeå University · Sundsvall and 1 other locations · NCT07797374

• Hormonal changes after two bariatric surgeries in super-obese people

  This study tests whether sleeve gastrectomy with duodenojejunal bypass leads to different hormone responses and less post-meal hypoglycemia than Roux-en-Y gastric bypass in people with extreme obesity.

  Recruiting Chulalongkorn University · Pathum Wan, Bangkok · NCT07747779

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.