Understanding how genes and environment affect T-cell immunity in sarcoidosis
Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis
This study is trying to understand how genes and environmental factors affect the immune system in people with sarcoidosis to see why the disease can vary so much from person to person.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 45 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | National Jewish Health Academic / other |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT03145922 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of epigenetic factors in the altered T-cell immunity observed in patients with sarcoidosis. It aims to identify how gene-environment interactions contribute to the disease's variability and severity. Participants will include individuals diagnosed with sarcoidosis, either confirmed by biopsy or through clinical manifestations. The study will analyze immune responses and potential environmental triggers that may influence the disease course.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 85 with a confirmed or suspected diagnosis of sarcoidosis who are scheduled for a biopsy.
Not a fit: Patients who are current smokers, on immunosuppressive therapy, pregnant, or unable to participate in study procedures will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of sarcoidosis, potentially reducing end organ damage and side effects from current therapies.
How similar studies have performed: While the specific approach of this study is novel, previous studies have shown that understanding the interplay between genetics and environmental factors can lead to significant insights in similar conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Between the ages of 18 and 85 * Diagnosis of sarcoidosis confirmed by either biopsy or by manifestations consistent with acute sarcoidosis in absence of other known diagnosis. * Have a suspected diagnosis of sarcoidosis and is scheduled to undergo a biopsy procedure to confirm a diagnosis of sarcoidosis. * Able to tolerate and willing to undergo study procedures Exclusion Criteria: * Current cigarette smoking or smoking within six months prior to the study * Currently or recently (\<6months) on immunosuppressive therapy * Pregnancy * Patient inability to participate in the study, such as undergo venipuncture and or BAL
Where this trial is running
San Francisco, California
- University of California, San Francisco (Parnassus) — San Francisco, California, United States (Recruiting)
Study contacts
- Study coordinator: Victoria Wang, BS
- Email: victoria.wang2@ucsf.edu
- Phone: 4154769225
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.