Understanding how exercise affects metabolism and recovery

Age and Sex Differences in the Metabolic Response to Exercise

This study is testing how exercise affects metabolism and recovery in healthy people of different ages to find the best exercise levels for good health.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 48 (estimated)
• Ages: 8 Years to 57 Years
• Sex: All
• Sponsor: University College, London (Academic / other)
• Locations: 1 site (London)
• Trial ID: NCT06088108 on ClinicalTrials.gov

What this trial studies

This research investigates the metabolic responses of healthy individuals to exercise and their recovery processes. Participants aged 8-10, 23-27, and 53-57 will undergo a treadmill exercise protocol at the University of East London SportsDock. The study will collect various biological samples and body measurements before, immediately after, and one hour post-exercise to analyze how different age groups respond metabolically. The goal is to identify optimal exercise levels that promote health while considering age and sex differences.

Who should consider this trial

Good fit: Ideal candidates are healthy, active individuals aged 8-10, 23-27, or 53-57 with a body mass index within specified ranges.

Not a fit: Patients with diseases, disabilities, or conditions impairing physical activity, as well as professional athletes, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help tailor exercise recommendations to optimize health outcomes across different age groups.

How similar studies have performed: While studies on exercise and metabolism exist, this specific approach focusing on age and sex differences in metabolic responses is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Aged 8-10, 23-27 or 53-57
2. Considered healthy without a disease, disability or other condition that would impair participation in physical activity.
3. Considered active.
4. A body mass index within the ranges of 19 to 24.5 (adults) or the 2nd and 99th percentile (children)

Exclusion Criteria:

1. Outside required age brackets
2. Having a disease, disability or other condition that would impair participation in physical activity.
3. Having an implanted cardiac pacemaker, defibrillator, or other electronic medical devices.
4. Receiving prescription medication one or more days every week over the past 3 months (some medications are permitted).
5. Related by blood to another participant.
6. Not willing at the time of recruitment to undergo blood sampling (adults only).
7. Pregnancy/breastfeeding (adults only).
8. Being a professional athlete.
9. Not being physically active.
10. Being a shift worker (night shift work for three or more days per week on more than two occasions in the six months before the visit day; adults only).
11. Recent weight loss of more than 5% of weight in the last 6 months.
12. Having a body mass index outside the range of 19 to 24.5 (adults) or outside the 2nd and 99th percentile (children)
13. Smoking/vaping.
14. Alcohol intake above a UK National Health Service (NHS) questionnaire cut-off.
15. Regular use of recreational drugs.
16. Not having reached menopause (for women aged 53-57 only).

Where this trial is running

London

• University of East London SportsDock — London, United Kingdom (Recruiting)

Study contacts

• Principal investigator: Jonathan Wells, Professor — University College, London
• Study coordinator: Evelyn Maniaki, Dr

Conditions Exercise; Metabolism; Recovery; Metabolomics