Understanding how exercise affects childhood cancer survivors' feelings
Childhood Cancer Survivors' Affective Response to Exercise
This study is trying to see how exercise affects the feelings of young adult survivors of childhood cancer, especially those who had leukemia, by looking at their emotional responses before and after physical activity.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 125 (estimated) |
| Ages | 18 Years to 39 Years |
| Sex | All |
| Sponsor | St. Jude Children's Research Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Memphis, Tennessee) |
| Trial ID | NCT05763290 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the feasibility of using the Personalized Single-Category Implicit Association Test (PSC-IAT) to assess the affective responses of young adult survivors of childhood cancer, specifically those who had acute lymphoblastic leukemia (ALL). Participants will undergo cognitive tasks before and after cardiovascular stress testing as part of the SJLIFE protocol, followed by qualitative interviews to explore their emotional and physical experiences during exercise. The study also includes the Behavioral Regulations in Exercise Questionnaire (BREQ-2) to validate the PSC-IAT results. The goal is to gain insights into the implicit biases towards exercise in this population.
Who should consider this trial
Good fit: Ideal candidates are young adult survivors of acute lymphoblastic leukemia aged 18-39 who are physically inactive.
Not a fit: Patients who have cognitive impairments or contraindications to stress testing may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help improve exercise interventions for childhood cancer survivors by understanding their emotional responses.
How similar studies have performed: While the specific use of PSC-IAT in this context may be novel, similar studies have shown the importance of understanding emotional responses to exercise in various populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants enrolled in St. Jude Lifetime Cohort (SJLIFE) aged 18-39 years at completion of on campus visit * Primary diagnosis of acute lymphoblastic leukemia (ALL) * No cranial radiation therapy (CRT) as part of treatment for ALL * Identify as physically inactive (do not meet Centers for Disease Control and Prevention (CDC) guidelines of 150 minutes of moderate physical activity per week or 75 minutes of vigorous physical activity per week) * Women who are not currently pregnant Exclusion Criteria: * Individuals who cannot speak, read, and/or understand English. * Individuals with an estimated IQ of \<70 and/or per PI discretion * Individuals with any contraindication to stress testing (i.e. cardiovascular complications) * Women who are currently pregnant
Where this trial is running
Memphis, Tennessee
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Megan Ware, MS, PhD — St. Jude Children's Research Hospital
- Study coordinator: Megan Ware, MS, PhD
- Email: referralinfo@stjude.org
- Phone: 888-226-4343
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.