Understanding how E. coli behaves in the human gut

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the ecological and evolutionary dynamics of Escherichia coli within the digestive system of healthy individuals. It aims to quantify the changes in E. coli strains in the gut microbiota, focusing on how these changes are influenced by both host and bacterial characteristics. By studying a large population of healthy volunteers, the research seeks to shed light on the colonization dynamics of E. coli, which is crucial for understanding its role in antibiotic resistance and virulence. The study will also explore the intra-host evolution of E. coli over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* healthy volunteer of both sexes between the ages of 18 and 65 years old included
* subject considered healthy after a thorough general examination (interrogation, physical examination)
* subject with normal transit with usually one molded saddle per day
* BMI between 18.5 and 35 kg / m² included

Exclusion Criteria:

* Subject living in an institution
* Known immunosuppression (HIV, concomitant immunosuppressive therapy, chemotherapy, long-term corticosteroids regardless of the dose\> 2 weeks in the last 6 months)
* Chronic gastrointestinal illness (Chronic Hemorrhagic Recto-colitis, Crohn's Disease)
* Any digestive resection except appendectomy and resection of polyps
* Subject with a history (s) of bacteremia
* Subject protected by law under guardianship or curator-ship
* Pregnant or lactating woman
* Subject deprived of liberty under judicial duress
* Lack of affiliation to a social security scheme
* Patient on State Medical Aid
* Absence of signed consent before entering the study

Where it's running

• Bichat Claude Bernard Hospital
  Paris, France Recruiting
• Bichat Hospital, Clinical Investigation Center
  Paris, France Recruiting

Study contacts

• Study coordinator: Xavier M DUVAL, MD, PhD
• Email: xavier.duval@aphp.fr
• Phone: +33 (0)1 40 25 71 48

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.