Understanding how different grains affect gut health and metabolism
Personalized Gastrointestinal Motility Responses to Dietary Fiber and Gut Microbial Metabolites
This study is testing how different types of grains affect gut health and metabolism in people by tracking their digestive responses and health-related substances after eating.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 21 Years to 63 Years |
| Sex | All |
| Sponsor | University of Illinois at Urbana-Champaign Academic / other |
| Locations | 1 site (Urbana, Illinois) |
| Trial ID | NCT06386471 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of whole and refined grains on gastrointestinal motility and cardiometabolic health. Participants will consume a Smartpill device to monitor their gut responses after eating these grains, while also tracking the production of metabolites related to health. The study aims to link dietary fiber intake with changes in gut microbiome and post-meal metabolite levels over an eight-hour period. By analyzing these interactions, the trial seeks to provide insights into personalized dietary recommendations.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy men and women without any significant gastrointestinal or metabolic disorders.
Not a fit: Patients with conditions such as diabetes, IBS, or those on specific medications that affect metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to tailored dietary guidelines that improve gut health and metabolic outcomes for individuals.
How similar studies have performed: Other studies have shown promising results in understanding the relationship between diet, gut health, and metabolic responses, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy men and women Exclusion Criteria: Physician-Diagnosed: * Diabetes Mellitus * Nutrient-malabsorption disorders * Intestinal Bowel Syndrome (IBS) * Intestinal Bowel Disease (IBD) * Bleeding-related disorders * Grain allergy * Psychological Disorders * Stenosis * Dysphasia History of: * Bariatric Surgery * Gallbladder removal * Eating disorders * Antibiotic administration (within the past three months) * Hormone therapy Currently: * Using statins * Pregnant, lactating, or postmenopausal * Taking oral hypoglycemic agents or insulin * Ingesting prescription fiber * Using cholesterol and bile acid absorption inhibitors * Ingesting nutrition supplements, not including a daily multivitamin (i.e. herbs, tinctures, and extracts) •Using recreational drugs or alcohol (within the past week) * Taking anti-histamines * Taking proton pump inhibitors * Taking antacids
Where this trial is running
Urbana, Illinois
- University of Illinois at Urbana-Champaign — Urbana, Illinois, United States (Recruiting)
Study contacts
- Study coordinator: Brett R Loman, PhD, RD
- Email: bloman2@illinois.edu
- Phone: 217-333-3451
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.