Understanding heart failure with preserved ejection fraction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to explore the mechanisms behind heart failure with preserved ejection fraction (HFpEF) by evaluating differences in cardiac structure, function, and fibrosis markers across various stages of heart failure. The study will investigate how risk factors like hypertension, diabetes, and obesity interact with age to influence HF risk, as well as the impact of precipitating factors such as myocardial ischemia and atrial fibrillation. Additionally, it will track HFpEF patients over time to identify prognostic factors by correlating baseline data with cardiovascular events.

Why it matters

Who can join: the full rules

Controls without an history of HF and previous cardiovascular disease will be recruited

Inclusion Criteria for HF patients:

Patients need to have typical symptoms and signs of HF, New York Heart Association (NYHA) functional class II or higher, N-terminal pro-B type natriuretic peptide (NT-proBNP) \>350pg/mL, or an hospitalization for HF within the previous 12 months. Left ventricular ejection fraction (LVEF) is required to be lower than 40% in patients with HFrEF and 50% or higher in HFpEF, with evident signs of diastolic dysfunction ( LA \> 34 ml/m²; E/e' \> 14; TR \>2.8 ms, septal e' velocity \< 7 cm/s or Lateral e' velocity \<10 cm/s)

Exclusion Criteria for HF patients:

Patients with severe valvular disease, infiltrative or hypertrophic cardiomyopathy, acute coronary syndrome in the previous 30 days, chronic obstructive pulmonary disease GOLD 3 or 4, congenital heart disease, pericardial disease, terminal renal failure (eGFR \< 15mL/min/1,73m²) or subjects requiring dialysis, atrial fibrillation with a ventricular response \> 140 bpm, severe anemia (hemoglobin \< 8 g/dL), liver dysfunction, and evolving cancer will be excluded

Where it's running

• Cliniques universitaires Saint Luc
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Anne Catherine Pouleur — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
• Study coordinator: Anne-Catherine Pouleur
• Email: anne-catherine.pouleur@uclouvain.be
• Phone: 003227646600

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.