Understanding glucose distribution in severely burned adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, observational, phase II cohort study aims to explore how the initial volume of glucose distribution changes during the first four days of treatment for severely burned patients. It focuses on the challenges of fluid resuscitation in burn victims, who often experience hypovolaemic shock and capillary leak syndrome. By administering a 30% intravenous glucose solution, the study seeks to quantify extracellular fluid volume as a potential marker for fluid overload, which is critical for optimizing patient management and improving outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years of age
* Patients hospitalized with burns of at least 30% of body surface area

  * By a thermal mechanism
  * At the CHR Metz-Thionville burn center
  * managed within the 8 hours post-burn
* Patient affiliated to a social security scheme
* Written consent obtained from the patient (or from the trusted person, family or relatives if the patient is unable to sign/express consent) or emergency inclusion if the patient is unable to express consent and neither the trusted support person nor any member of the family or relatives is present at the time of inclusion.

Exclusion Criteria:

* Diabetic patients on insulin
* Patient with a CONTRAINDICATION to GLUCOSE 30% PROAMP, solution for injection
* Patients with pre-hospital cardiac arrest
* extra corporeal circulation patient: Extra Corporeal Membranous Oxygenation (ECMO) or Extra Corporeal Life Support (ECLS) or CRRT (Continuous Renal Replacement Therapy)
* patient without a central venous line or arterial catheter
* Patient moribund or immediately subject to therapeutic limitation
* Impossibility of trans-pulmonary thermodilution monitoring (vascular access difficulties)
* Pregnant, parturient or breast-feeding women
* Patient under guardianship, curatorship or safeguard of justice
* Cognitive impairment or language barrier

Where it's running

• CHR Metz-Thionville/Hopital de Mercy
  Metz, France Recruiting

Study contacts

• Principal investigator: Serge LE TACON, MD — CHR Metz Thionville Hopital de Mercy
• Study coordinator: Arpiné EL NAR, PhD
• Email: projet-recherche-clinique@chr-metz-thionville.fr
• Phone: 0033387557766

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.