Understanding follicular fluid markers and IVF outcomes
Human Follicular Fluid Markers and Reproductive Outcomes in IVF: Relevant Factors for the Oocyte's Developmental Potential
Universitätsklinik fur Frauenheilkunde, Inselspital Bern · NCT05893238
This study is trying to see if certain markers in follicular fluid can help predict how well IVF will work for couples trying to conceive.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 42 Years |
| Sex | All |
| Sponsor | Universitätsklinik fur Frauenheilkunde, Inselspital Bern (other) |
| Locations | 1 site (Bern) |
| Trial ID | NCT05893238 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between follicular fluid markers and reproductive outcomes in couples undergoing In Vitro Fertilisation (IVF). It involves measuring various laboratory values in blood, follicular fluid, and sperm, alongside lifestyle questionnaires, to identify factors that may enhance IVF success. The study will compare outcomes between natural cycle IVF and conventional IVF treatments, enrolling approximately 200 couples at a single site in Bern. Data will be collected and analyzed to assess the predictive power of these parameters on IVF success.
Who should consider this trial
Good fit: Ideal candidates for this study are couples undergoing In Vitro Fertilisation, either through natural cycle or conventional methods.
Not a fit: Patients who may not benefit from this study include those with significant medical conditions, genetic disorders, or poor sperm quality.
Why it matters
Potential benefit: If successful, this study could lead to improved IVF treatment strategies and higher success rates for couples facing infertility.
How similar studies have performed: While there have been studies on IVF outcomes, this specific approach focusing on follicular fluid markers is relatively novel and exploratory.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Willing to participate * Written consent * Couples undergoing In Vitro Fertilisation (natural cycle or conventional IVF) Exclusion Criteria: * Not willing to participate * Missing consent * Female of the couple does not want to participate or missing consent * Language barrier * Medical freezing * Social freezing * Thawed cycles * Genetic disorders * Preimplantation genetic testing (PGT) * Medication for chronic condition * Surgery in the last 4 weeks * Significant trauma in the last 90 days * Severe reduced sperm quality * Kryosperm * Poor responder or expected poor response
Where this trial is running
Bern
- Inselspital Bern, Frauenklinik — Bern, Switzerland (RECRUITING)
Study contacts
- Study coordinator: Janna Pape, MD
- Email: janna.pape@insel.ch
- Phone: 0041316321010
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: IVF, Infertility, Natural IVF, Follicular Fluid, Oxidation-reduction potential, Gonadotrophin, Lifestyle