Understanding fat tissue characteristics in type 2 diabetes and obesity
Regional Adipose Tissue Characteristics in Type II Diabetes
Concordia University, Montreal · NCT06599047
This study looks at the different types of fat in people with obesity, type 2 diabetes, and those who are lean to see how they affect health and each other.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 140 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Concordia University, Montreal (other) |
| Locations | 1 site (Montreal, Quebec) |
| Trial ID | NCT06599047 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the characteristics of adipose tissue in individuals with obesity, type 2 diabetes, and lean individuals. It will recruit 140 participants aged 18-65, dividing them into three groups: those with obesity, those with diabetes, and lean individuals. The study will focus on how abdominal fat contributes to metabolic diseases and how these diseases may affect fat tissue. Participants will be recruited from a hospital in Montreal, specifically those awaiting bariatric or general abdominal surgery.
Who should consider this trial
Good fit: Ideal candidates include men and women aged 18-65 who are either obese and anticipating bariatric surgery or lean individuals awaiting general abdominal surgery.
Not a fit: Patients with uncontrolled hypothyroidism, renal impairment, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into the mechanisms linking adipose tissue characteristics to type 2 diabetes and obesity, potentially leading to improved treatment strategies.
How similar studies have performed: While there have been studies on adipose tissue and metabolic diseases, this specific approach to understanding the mechanisms in bariatric patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men, premenopausal and postmenopausal females between 18-65 years * Anticipating having bariatric surgery (participants with obesity) or general surgery in the abdominal area (normal weight participants) with a duration of less than 1.5 hours. * BMI 30 kg / m2 (participants with obesity) * Weight Stable for a minimum of two months prior to the first pre-op visit Exclusion Criteria: * Smoking * Renal impairment defined by creatinine clearance; 60 ml/minute * Uncontrolled hypothyroidism * No comorbidity other than diabetes type II Exceptions: controlled hypertension, hypothyroidism controlled, controlled dyslipidemia * Use prescribed medication that affect our outcomes E.g. Exceptions include metformin, DPP-4 inhibitors, inhibitors of the α-glucosidase, hypotensive with a stable dose for 3 months lipid lowering with a stable dose for 3 months.
Where this trial is running
Montreal, Quebec
- Concordia University (School of Health) — Montreal, Quebec, Canada (RECRUITING)
Study contacts
- Study coordinator: Sylvia Santosa, R.D., PhD.
- Email: s.santosa@concordia.ca
- Phone: 514-848-2424
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Obesity and Type 2 Diabetes, Bariatric Patients Undergoing Bariatric Surgery, Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery, Adipose Tissue Inflammation, obesity, Type 2 diabetes, Bariatric Surgery, Adipose Tissue Characterization