Understanding Drug Resistance in High Grade Gliomas
Vacuolar ATPase and Drug Resistance of High Grade Gliomas: a Study to Investigate Possible Therapeutic Roles for Proton Pump Inhibitors
University of Milano Bicocca · NCT05328089
This study looks at how a specific part of brain tumors called glioblastoma multiforme can resist treatment, by examining tumor samples from patients to find clues that could lead to better therapies.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | University of Milano Bicocca (other) |
| Drugs / interventions | radiation, chemotherapy |
| Locations | 1 site (Monza) |
| Trial ID | NCT05328089 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on glioblastoma multiforme (GBM), a type of brain tumor known for its aggressive nature and limited treatment options. It aims to investigate the role of vacuolar ATPase in the metabolism of GBM and its contribution to drug resistance. The study will analyze tumor samples from patients undergoing surgery for suspected gliomas to identify molecular patterns associated with tumor recurrence. By understanding the metabolic processes and cellular characteristics of GBM, the research seeks to uncover potential targets for improving treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have a suspected glioma and are scheduled for craniotomy.
Not a fit: Patients under 18 years old or those with brain tumors other than gliomas will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new therapeutic strategies that enhance treatment efficacy for patients with glioblastoma.
How similar studies have performed: Previous studies have explored similar metabolic pathways in gliomas, indicating potential for success in this area of research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients =\> 18 years old; * Patients with an intra-axial brain tumor suspect for glioma; * Patients able to sign a consent form for research purpose; * Patients with planned craniotomy for brain tumor resection. Exclusion Criteria * Patients \< 18 years old; * Patients with known brain tumors different than gliomas; * Patients unable to sign a consent form for research purpose; * Patients undergoing brain tumor biopsy; * Patients with poor intra-operative or small surgical sample for histopathological diagnosis; * Histology diagnostic for tumors different than gliomas.
Where this trial is running
Monza
- Azienda Socio Sanitaria Territoriale Monza - Ospedale San Gerardo — Monza, Italy (RECRUITING)
Study contacts
- Study coordinator: Carlo G. Giussani, Prof.
- Email: carlo.giussani@unimib.it
- Phone: 0392336033
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Glioblastoma Multiforme, V-ATPAse, Cancer Stem Cells, Glioma Metabolism