Understanding cognitive decline after stroke and its relation to blood-brain barrier disruption
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
This study looks at how problems with the blood-brain barrier during a stroke might affect thinking and memory in stroke survivors over the next three years.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT05556395 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between global disruption of the blood-brain barrier during an ischemic stroke and the risk of cognitive decline over the following three years. By utilizing MRI scans to assess cerebral small vessel disease and blood-brain barrier integrity, researchers will investigate how these factors contribute to post-stroke cognitive impairment. The study seeks to clarify the mechanisms behind accelerated cognitive decline in stroke survivors, potentially leading to better predictive models for cognitive outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who have experienced an acute ischemic stroke and have undergone MRI scans that include perfusion imaging.
Not a fit: Patients who are unable to participate in telephone-based cognitive assessments will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that help identify stroke patients at higher risk for cognitive decline, allowing for targeted interventions.
How similar studies have performed: Previous studies have indicated a link between blood-brain barrier disruption and cognitive decline, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute ischemic stroke demonstrated on an MRI scan that includes perfusion imaging with an exogenous contrast agent Exclusion Criteria: * Inability to perform telephone-based cognitive assessments
Where this trial is running
Baltimore, Maryland
- Johns Hopkins Hospital — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Richard Leigh, MD — Johns Hopkins University
- Study coordinator: Diane Echavarria
- Email: dechava1@jhu.edu
- Phone: 410 502 5355
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.