Understanding cervical cancer treatment and characteristics in Italy
Official title: RETRACE Study - Retrospective Observational Study Evaluating Disease Characteristics and Treatment Landscape of High-risk Locally Advanced (LA) or Recurrent / Metastatic (R/M) Cervical Cancer in Italy
Run by MSD Italia S.r.l. · NCT06771193 · Data updated 2026-11-12
This study looks at how patients in Italy with advanced or recurring cervical cancer are treated and what their experiences are like.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 200 (estimated) |
| Sponsor | MSD Italia S.r.l. Industry-sponsored |
| Drugs / interventions | Pembrolizumab, Levantinib |
| Locations | 11 sites (Bologna, Bologna and 10 other locations) |
| Status | Recruiting |
| Started | December 17, 2024 |
| Main results expected | December 2025 |
| Study ends | December 2025 |
| Registry record updated | July 20, 2025 |
| Trial ID | NCT06771193 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older diagnosed with locally advanced, recurrent, or metastatic cervical cancer who received treatment between January 2018 and December 2021.
✕Probably not a fit
Patients currently participating in pharmacological clinical trials or those treated with specific medications like Pembrolizumab, Olaparib, or Levantinib may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to analyze the characteristics and treatment patterns of patients with locally advanced or recurrent/metastatic cervical cancer in Italy. By reviewing medical records from oncologic clinics between January 2018 and December 2021, the study will capture data on patient demographics, disease characteristics, and treatment approaches. The study will categorize patients based on risk levels and assess differences in treatment strategies. This retrospective analysis will provide valuable insights into the management of cervical cancer in the specified population.
Why it matters
Potential benefit: If successful, this study could enhance understanding of cervical cancer treatment patterns, potentially leading to improved patient outcomes.
How similar studies have gone: While this study is observational and retrospective, similar studies have provided valuable insights into treatment patterns and outcomes in cancer care.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient (or their legally acceptable representatives) must have signed and dated the Informed Consent \& Privacy Form (ICF) * Age ≥18 years * Diagnosis of a cervical cancer * Locally advanced stage (not suitable for curative surgery) or recurrent or metastatic disease * Any treatment received between January 2018 and December 2021 for advanced disease Exclusion Criteria: * Patients participating in a pharmacological clinical trial for the treatment of advanced disease * Patients who participated in a clinical trial * Patients who were administered with Pembrolizumab, Olaparib or Levantinib or medications from these class of drugs
Where it's running
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Oncologia Medica Policlinico Sant'Orsola Malpighi
Bologna, Bologna, Italy Recruiting -
Ginecologia ed Ostetricia A.O. Cannizzaro
Catania, Catania, Italy Recruiting -
Oncologia Medica 1 IRCCS Ospedale Policlinico San Martino
Genova, Genova, Italy Recruiting -
Unità di Ginecologia Oncologica Medica IRCCS Ospedale San Raffaele
Milan, Milano, Italy Recruiting -
Unità Ostetricia, Ginecologia e Ginecologia Oncologica medica Humanitas San Pio X
Milan, Milano, Italy Recruiting -
Oncologia A.O.U. di Modena - Policlinico
Modena, Modena, Italy Recruiting
Show 5 more locations
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U.O.S. Trattamenti Innovativi dell'utero Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale
Naples, Napoli, Italy Recruiting -
UOC Oncologia Medica ed Ematologia Azienda Ospedaliera Universitaria Luigi Vanvitelli
Naples, Napoli, Italy Recruiting -
IRCCS Centro di Riferimento Oncologico (CRO)
Aviano, Pordenone, Italy Recruiting -
U.O.C. Ginecologia Oncologica Policlinico Agostino Gemelli
Roma, Roma, Italy Recruiting -
UOC Oncologia Medica Ospedale Dell'Angelo - Mestre Azienda USL3 Serenissima
Mestre, Venezia, Italy Not yet recruiting
Study contacts
- Study coordinator: Stefania Lopez
- Email: info.studiclinici@opisresearch.com
- Phone: +39 03626331
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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PD-1 versus PD-L1 immunotherapy combined with chemotherapy, with or without bevacizumab, for advanced cervical cancer.
This trial tests whether giving PD-1 or PD-L1 immunotherapy alongside chemotherapy, with or without bevacizumab, helps adults with metastatic, persistent, or recurrent cervical cancer.
-
SHR-A2102 versus investigator's choice chemotherapy for recurrent or metastatic cervical cancer after platinum and PD-(L)1 therapy
This trial tests whether SHR-A2102 works better than standard chemotherapy for people with recurrent or metastatic cervical cancer whose disease progressed after platinum-based chemotherapy and PD-(L)1 inhibitors.
-
Comparing neoadjuvant chemoimmunotherapy and concurrent chemoradiotherapy for locally advanced cervical cancer
This study is testing whether a new treatment combining chemoimmunotherapy and surgery can help people with locally advanced cervical cancer do better than the standard treatment of chemo and radiation.
-
Neoadjuvant immunochemotherapy for PD-L1-negative locally advanced cervical cancer
This study is testing a new treatment that combines chemotherapy with a drug called Camrelizumab to see if it can help people with PD-L1-negative locally advanced cervical cancer before surgery.
-
Combination treatment for recurrent or metastatic cervical cancer
This study is testing if adding a new treatment called PRGN-2009 to pembrolizumab can help people with recurrent or metastatic cervical cancer who haven't responded to pembrolizumab alone.
-
Assessing the effects of radiotherapy on tumors in cervical and pancreatic cancer
This study is testing how radiotherapy affects tumors in patients with locally advanced cervical and pancreatic cancer by collecting samples and using special imaging before, during, and after treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.