Understanding brain control networks in survivors of the November 13 attacks
Official title: Etude Longitudinale En Imagerie Cérébrale, En Neuropsychologie, Et En Psychopathologie, Des Conséquences D'un Événement Traumatique
Run by Institut National de la Santé Et de la Recherche Médicale, France · NCT02810197 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study looks at how the brains of people who survived the November 13 attacks in Paris work differently over time compared to those who weren't exposed, to see if this affects their memories and feelings related to PTSD.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France Government |
| Locations | 1 site (Caen, Calvados) |
| Trial ID | NCT02810197 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 18 to 55 who were present at the scene of the attacks or lived in the affected neighborhoods.
✕Probably not a fit
Patients with severe psychiatric disorders prior to the attacks or those currently pregnant will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the resilience and modification of brain control networks in individuals who survived the November 13, 2015, terrorist attacks in Paris. It involves a multiwave longitudinal neuroimaging approach, collecting both structural and functional brain imaging data at various intervals (8-12 months, 3 years, and 6 years) post-trauma. Participants include those directly exposed to the attacks and a control group of non-exposed individuals, allowing for a comparative analysis of brain function and structure related to post-traumatic stress disorder (PTSD). The study aims to explore how memory suppression techniques may differ between these groups and how this affects the experience of intrusive memories associated with PTSD.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of PTSD and lead to improved therapeutic strategies for managing intrusive memories.
How similar studies have gone: While this approach is novel in the context of the specific traumatic event studied, similar neuroimaging studies have shown promise in understanding PTSD mechanisms.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants between 18 and 55 years old. * Present at the scene of the attacks the evening of 13 November 2015 or inhabitant of one of the neighbourhood affected by the attacks (exposed group), or persons were not in Paris on the evening of the attacks and not residing in Paris and its region (unexposed group). * Affiliated to the French national health care system * Have a good knowledge of the French language * Right-handed * Body mass less than or equal to 35kg/m2 * Signed written consent form Exclusion Criteria: * Pregnancy or intent to get pregnant * Person deprived of their liberty * Person admitted to a health or social institution for purposes other than research * Minor * Person subjected to an exclusion period related to another protocol * History of severe psychiatric disorders before the attacks : psychotic disorders, bipolar disorder, obsessive compulsive disorder and / or substance use disorders (excluding tobacco addiction) * Use of medication that may interfere with cognitive or cerebral functioning * Presence of visual or hearing troubles that may compromise participant's ability to participate in the study * MRI Contraindications
Where it's running
-
GIP Cyceron
Caen, Calvados, France Recruiting
Study contacts
- Principal investigator: Vincent de La Sayette, MD — University Hospital, Caen
- Study coordinator: Pierre Gagnepain, PhD
- Email: gagnepain@cyceron.fr
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Anger, Social Thinking, and PTSD in French Veterans
This study tests whether PTSD in former French military personnel is linked to higher anger through changes in social thinking abilities.
-
TSND-201 treatment for PTSD in adults
This study tests two doses of TSND-201 or placebo to see if it helps adults with PTSD.
-
Long-term outcomes after Hyperbaric Oxygen Therapy in veterans with TBI, PCS, or PTSD
This study tests whether benefits from HBOT persist over time for veterans with brain injury or related conditions.
-
SEE FAR CBT for Adults With PTSD
This 12-week, one-on-one SEE FAR CBT program tests a trauma-focused therapy to see if PTSD symptoms improve in adults 18 and older.
-
Brief SEE FAR CBT: a short, focused therapy for adults with PTSD
A 6-session Brief SEE FAR CBT treatment is tested against usual dynamic psychotherapy for adults with PTSD to see if it reduces symptoms.
-
MDMA Therapy for PTSD in Veterans
This phase 2 study tests a fixed 120 mg dose of MDMA, followed by a 60 mg supplemental dose, plus therapy, to see if it helps adults who are veterans with PTSD.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.