Ultrasound-guided carpal tunnel release procedure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the efficacy and safety of an innovative ultrasound-guided technique for releasing the transverse carpal ligament in patients with carpal tunnel syndrome. The approach aims to minimize trauma and postoperative recovery time compared to traditional surgical methods. Participants will undergo the loop carpal tunnel release procedure if they meet specific eligibility criteria, including age and symptom severity. The study focuses on patients who have not responded to conservative treatments for their condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged between 40 and 70 years;
2. Exhibiting symptoms consistent with carpal tunnel syndrome (e.g., finger numbness, tingling, weakness, or pain; symptoms aggravated by repetitive or sustained gripping; symptoms worsening at night) and signs (sensory impairment or weakness in the hand; positive Tinel's sign or Phalen's test for the median nerve);
3. Meeting the diagnostic criteria for typical or possible carpal tunnel syndrome based on the Katz hand diagram for carpal tunnel syndrome \[14\];
4. Ultrasound indicating thickening of the transverse carpal ligament, compressing the median nerve;
5. Ineffective conservative treatment (e.g., immobilization, oral NSAIDs, local corticosteroid injections) for more than 3 months;
6. Signing the informed consent form.

Exclusion Criteria:

1. Ultrasound examination reveals bifurcation of the median nerve or the presence of a persistent median artery at the carpal tunnel entrance, or compression at the carpal tunnel caused by cysts, tumors, or fracture fragments;
2. Systemic infection or local infection at the surgical site;
3. Severe coagulation disorders;
4. Previous carpal tunnel syndrome surgery on the affected side for this operation;
5. Patients with uncontrolled epilepsy, cervical radiculopathy, or diabetic peripheral neuropathy;
6. Allergy to local anesthetics;
7. Inability to complete the questionnaire due to language or cognitive impairments;
8. Patients with severe heart, lung, liver, or brain diseases;
9. Patients with mental illnesses;
10. Participation in other clinical trials within the last three months;
11. Pregnant or breastfeeding women.

Where it's running

• Sun Yat-sen Memorial Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Jingyi Hou
• Email: houjingyi246@126.com
• Phone: 15920530546

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Carpal tunnel release vs placebo surgery in Finland

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• High-intensity laser therapy for carpal tunnel syndrome

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• Ultrasound-guided needle release plus dextrose (D5W) hydrodissection for carpal tunnel syndrome

  This trial tests whether combining ultrasound-guided partial release of the transverse carpal ligament with dextrose (D5W) hydrodissection provides better symptom relief for adults with carpal tunnel syndrome and at least moderate symptoms.

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• A mix of vitamins to help recovery after carpal tunnel surgery

  This will test whether taking alpha-lipoic acid, vitamin E, and B vitamins helps adults recover better after carpal tunnel release surgery.

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• Symptom spread and pain sensitivity in carpal tunnel syndrome

  This test looks at whether people with carpal tunnel syndrome whose symptoms spread beyond the usual finger area have higher central pain sensitivity, using a questionnaire and pressure pain testing.

  Recruiting Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · Istanbul, Usküdar · NCT07114913

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.