Ultrafast ultrasound imaging for congenital heart disease in children
Official title: Ultrafast Ultrasound Imaging: Application in Pediatric Cardiology: Cardiac Ultrafast
Run by University Hospital, Bordeaux · NCT07255144 · Data updated 2026-11-12
This project will try ultrafast ultrasound to measure heart muscle stiffness and blood flow in children with congenital heart disease.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 1 site (Pessac, France) |
| Status | Recruiting |
| Started | March 11, 2025 |
| Main results expected | March 11, 2028 |
| Study ends | March 11, 2028 |
| Registry record updated | November 28, 2025 |
| Trial ID | NCT07255144 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children of any age with congenital heart disease seen at the CHD department, plus otherwise-healthy children coming for check-ups or with small ASD/PFO, who have French social security coverage and parental or legal guardian consent.
✕Probably not a fit
Children with arrhythmias, segmental kinetic disorders, implanted pacemakers/defibrillators, or those who cannot tolerate ultrasound gel are excluded and would not benefit from this imaging approach in the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will use an open-platform Verasonics ultrafast ultrasound system to capture very high-frame-rate cardiac images and derive measures of myocardial stiffness and perfusion in pediatric CHD patients. The observational protocol enrolls CHD patients of any age seen at the cardiology department and includes a comparison group of otherwise-healthy children or those with small ASD/PFO. Key exclusions are arrhythmia, segmental wall motion disorders, implanted cardiac devices, anechoic imaging, and allergy to ultrasound gel. Collected UFUS metrics will be compared to standard echocardiographic findings to look for signals related to impaired diastolic filling.
Why it matters
Potential benefit: If successful, UFUS could provide quicker, noninvasive measures of heart stiffness and perfusion to better detect diastolic problems and help guide treatment in children with CHD.
How similar studies have gone: Ultrafast ultrasound has shown promising results for myocardial mechanics and perfusion in adult and preclinical studies, but its use specifically in pediatric CHD is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Every patient of CHD department of any age or any sex: * Patients with CHD * General population patients in good general health as evidenced by medical history coming to our department for a check-up OR diagnosed with small Atrial Septal Defect or small Patent Foramen Ovale * Social security affiliation * Parental or legal guardian's non-opposition Exclusion Criteria: * Arrhythmia * Segmental kinetic disorder. * Pacemaker or multisite stimulation, defibrillator, * Anechoic * Allergy to echocardiography gel.
Where it's running
-
Hôpital Cardiologique Haut Lévêque
Pessac, France, France Recruiting
Study contacts
- Study coordinator: Olivier VILLEMAIN, MD, PhD
- Email: olivier.villemain@chu-bordeaux.fr
- Phone: +33 5 24 54 94 79
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.