Two Ways of Taking Olomorasib in Healthy Volunteers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 1 study compares two administration methods of olomorasib (the test and reference forms) in healthy volunteers. Participants will undergo a 6-week participation period, including a single 7-night stay at the Clinical Research Unit. The study collects pharmacokinetic data and safety information, with close monitoring of vital signs and laboratory tests. Eligible participants must be healthy, within specified BMI, and able to stay overnight at the site. The sponsor is Eli Lilly, and the study is conducted at Fortrea Clinical Research Unit in Daytona Beach, Florida.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring.
* Have a body mass index (BMI) within the range 18.0 to 30.0 kilograms per square meter (kg/m2)
* Participants assigned male at birth (AMAB) or assigned female at birth (AFAB) who are individuals not of childbearing potential (INOCBP)
* Able to comply with the 7-night stay at the study site.

Exclusion Criteria:

* History or presence of any of the following conditions, such as metabolic disease, biliary disease, gastrointestinal disease, hematological disease, neurological disease, presence of hepatic disease, active cardiovascular disease or history of myocardial infarction or unstable angina within 6 months prior to the first dose of olomorasib
* Have an abnormal blood pressure or pulse rate
* Have known allergies to olomorasib or related compounds.
* Have clinically significant history of multiple or severe drug hypersensitivity reactions or drug allergies as determined by the investigator, such as anaphylaxis, hepatotoxicity, or treatment with steroids or epinephrine.
* History or presence of any illness or psychiatric condition that would interfere with the ability to provide informed consent or comply with study instructions,
* Show evidence of Human immunodeficiency virus (HIV) infection or positive HIV antibodies at screening.
* Have a positive hepatitis C antibody test unless a confirmatory HCV RNA test is negative.
* Have evidence of hepatitis B at screening that is, positive test for hepatitis B surface antigen, Hepatitis B Virus Deoxyribonucleic Acid (HBV DNA) or both.

Where it's running

• Fortrea Clinical Research Unit
  Daytona Beach, Florida, United States Recruiting

Study contacts

• Study coordinator: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
• Email: LillyTrials@Lilly.com
• Phone: 1-317-615-4559

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effects of Exercise Snacks on Muscle Size and Strength in Healthy Young Adults

  This study tests whether many small workouts throughout the week can build muscle size and improve strength in healthy, untrained young adults compared with the usual twice-weekly workouts.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07760597

• ORX489 safety and dosing in healthy adults ages 18 to 60

  This will test whether ORX489 tablets are safe, well tolerated, and how they are processed in the body in healthy men and women aged 18 to 60.

  Recruiting Phase 1 Centessa Pharmaceuticals (UK) Limited · Lincoln, Nebraska · NCT07413666

• ReHIIT Prehabilitation in Healthy Adults

  This pilot tests a combined resistance and high‑intensity interval training program to establish baseline physiology in healthy adults before applying findings to cancer patients.

  Recruiting University of Nottingham · Derby, Derbyshire · NCT07313332

• Safety and drug levels of a 3‑month naltrexone implant (BICX104) with or without bupropion versus monthly Vivitrol injections

  This will test whether a three‑month naltrexone implant (BICX104), given alone or with extended‑release bupropion, is safe and keeps steady drug levels compared with monthly Vivitrol injections in healthy adults.

  Recruiting Phase 1 BioCorRx Pharmaceuticals Inc · Miami, Florida · NCT07269873

• Compare two forms and doses of vonafexor and see if the high dose interacts with other drugs

  This test looks at how two doses and two formulations of vonafexor (EYP651 and vonafexor acid) are absorbed and processed in healthy adults and whether the high dose interacts with common medicines.

  Recruiting Phase 1 Enyo Pharma · Gières · NCT07251153

• Low-frequency vibrating mat for sleep and daily stress recovery

  This test will see if using a low-frequency vibrating mat at home for three weeks improves stress recovery, sleep quality, mood, and attention in healthy adults aged 18-45.

  Recruiting Florida International University · Miami, Florida · NCT07221318

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.