Two exergame-based cognitive-motor rehabilitation programs for people with Huntington's disease
CARE-MH: Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
This research tests whether two different exergame-based programs can help thinking, movement, and behavior in adults with early-stage Huntington's disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Angers Government |
| Locations | 1 site (Angers) |
| Trial ID | NCT06807892 on ClinicalTrials.gov |
What this trial studies
Adults with genetically confirmed stage 1–2 Huntington's disease and specified motor and cognitive scores will be enrolled and receive one of two supervised cognitive-motor rehabilitation programs delivered via exergames (either a synergistic or a sequential approach). Interventions combine physical activity and cognitive stimulation through interactive game-like exercises adapted to motor and cognitive abilities. Outcomes will include standardized measures of motor function (including UHDRS motor items), cognitive tests, and behavioral scales collected before and after the intervention to compare effects between the two approaches. The protocol targets feasibility and preliminary clinical signals rather than claiming definitive therapeutic benefit.
Who should consider this trial
Good fit: Adults with genetically confirmed stage 1–2 Huntington's disease who meet the motor (UHDRS ≥ 5) and cognitive (CFT > 6 and ≤ 13) entry criteria, can give informed consent (or have third-party consent), and can understand French are the intended participants.
Not a fit: People with advanced disease, severe cognitive deficit (MMSE < 16), major psychiatric or neurological conditions that affect cognition, pregnant or breastfeeding women, or those who cannot understand French are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the programs could improve or stabilize motor, cognitive, and behavioral symptoms using accessible exergame-based rehabilitation.
How similar studies have performed: Exergame and combined physical-cognitive programs have shown encouraging results in Parkinson's disease, multiple sclerosis, and other conditions, but rigorous evidence specifically in Huntington's disease remains limited and preliminary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults at inclusion * Huntington's disease diagnosed and confirmed by genetic analysis * Patient with stage 1-2 HD with a motor UHDRS score ≥ 5 and a CFT between 6 \< CFT ≤ 13 * Patient with written informed consent or third-party consent * Affiliated or beneficiary of a social security scheme Exclusion Criteria: * Poor understanding of the French language * Participation in interventional research modifying management * History likely to interfere with cognition (established stroke, sequelae of traumatic brain injury, active epilepsy, learning disorders, alcohol dependence syndrome, drug use, psychiatric disorders), severe cognitive deficit (MMSE \<16), clinically significant pathological condition which, in the investigator's opinion, could interfere with the subject's safety or the evaluation of study results * Pregnant or breast-feeding women * Persons deprived of their liberty by administrative or judicial decision * Persons under compulsory psychiatric care
Where this trial is running
Angers
- Angers University hospital — Angers, France (Recruiting)
Study contacts
- Study coordinator: Clarisse SCHERER GAGOU, MD
- Email: ClScherer@chu-angers.fr
- Phone: +33 2 41 35 55 46
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.