Two exergame-based cognitive-motor rehabilitation programs for people with Huntington's disease
Official title: CARE-MH: Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
Run by University Hospital, Angers · NCT06807892 · Data updated 2026-11-12
This research tests whether two different exergame-based programs can help thinking, movement, and behavior in adults with early-stage Huntington's disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University Hospital, Angers Government |
| Locations | 1 site (Angers) |
| Status | Recruiting |
| Started | July 31, 2025 |
| Main results expected | October 17, 2027 |
| Study ends | October 17, 2027 |
| Registry record updated | March 17, 2026 |
| Trial ID | NCT06807892 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with genetically confirmed stage 1–2 Huntington's disease who meet the motor (UHDRS ≥ 5) and cognitive (CFT > 6 and ≤ 13) entry criteria, can give informed consent (or have third-party consent), and can understand French are the intended participants.
✕Probably not a fit
People with advanced disease, severe cognitive deficit (MMSE < 16), major psychiatric or neurological conditions that affect cognition, pregnant or breastfeeding women, or those who cannot understand French are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with genetically confirmed stage 1–2 Huntington's disease and specified motor and cognitive scores will be enrolled and receive one of two supervised cognitive-motor rehabilitation programs delivered via exergames (either a synergistic or a sequential approach). Interventions combine physical activity and cognitive stimulation through interactive game-like exercises adapted to motor and cognitive abilities. Outcomes will include standardized measures of motor function (including UHDRS motor items), cognitive tests, and behavioral scales collected before and after the intervention to compare effects between the two approaches. The protocol targets feasibility and preliminary clinical signals rather than claiming definitive therapeutic benefit.
Why it matters
Potential benefit: If successful, the programs could improve or stabilize motor, cognitive, and behavioral symptoms using accessible exergame-based rehabilitation.
How similar studies have gone: Exergame and combined physical-cognitive programs have shown encouraging results in Parkinson's disease, multiple sclerosis, and other conditions, but rigorous evidence specifically in Huntington's disease remains limited and preliminary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults at inclusion * Huntington's disease diagnosed and confirmed by genetic analysis * Patient with stage 1-2 HD with a motor UHDRS score ≥ 5 and a CFT between 6 \< CFT ≤ 13 * Patient with written informed consent or third-party consent * Affiliated or beneficiary of a social security scheme Exclusion Criteria: * Poor understanding of the French language * Participation in interventional research modifying management * History likely to interfere with cognition (established stroke, sequelae of traumatic brain injury, active epilepsy, learning disorders, alcohol dependence syndrome, drug use, psychiatric disorders), severe cognitive deficit (MMSE \<16), clinically significant pathological condition which, in the investigator's opinion, could interfere with the subject's safety or the evaluation of study results * Pregnant or breast-feeding women * Persons deprived of their liberty by administrative or judicial decision * Persons under compulsory psychiatric care
Where it's running
-
Angers University hospital
Angers, France Recruiting
Study contacts
- Study coordinator: Clarisse SCHERER GAGOU, MD
- Email: ClScherer@chu-angers.fr
- Phone: +33 2 41 35 55 46
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Computerized social cognition training for adults with Huntington's disease
This project will test whether a computerized program can help adults with Huntington's disease better understand other people's emotions and social cues.
-
Postoperative Rectal Pain Relief With Ear Vagus Nerve Stimulation
This study tests whether stimulating the vagus nerve through an ear-based device can reduce pain after anal or rectal surgery.
-
Perineural Catheter for Hindfoot Surgery Pain Control
This study tests whether a continuous perineural catheter delivering local anesthetic after hindfoot surgery helps with pain more than standard care.
-
Screening for blood clots in adults with acute heart failure
This trial tests whether a guideline-based screening approach can detect pulmonary embolism in adults admitted with acute heart failure.
-
Long-term overwintering on the Kerguelen Islands and its effects on the immune system
This project will test how living as an overwintering team member on the Kerguelen Islands for about a year affects the immune system in healthy adults.
-
Intubation strategies for adults with acute hypoxemic respiratory failure
This trial will test two different rules for when to intubate adults with acute hypoxemic respiratory failure to see which approach keeps patients safer while avoiding unnecessary mechanical ventilation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.