Tumor vaccines for treating glioma and solid tumors
Preclinical and Clinical Research on Therapeutic Vaccines for Solid Tumors
This study is testing whether a new type of vaccine made from immune cells can help people with brain tumors live longer and feel better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 340 (estimated) |
| Sex | All |
| Sponsor | Huashan Hospital Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06102837 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on glioma, a type of brain tumor with limited treatment options and poor prognosis. It aims to evaluate the effectiveness of dendritic cell (DC) vaccines in improving patient outcomes, particularly in extending overall survival for those with newly diagnosed and recurrent glioblastoma. The study will involve patients from the Department of Neurosurgery at Huashan Hospital, who will provide tissue samples for analysis. The research leverages advancements in immunotherapy and aims to contribute to the development of new treatment strategies for solid tumors.
Who should consider this trial
Good fit: Ideal candidates include glioma patients or non-tumor patients with specific neurological conditions who can provide tissue samples for analysis.
Not a fit: Patients currently participating in other clinical trials or pregnant women may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new immunotherapy option that significantly improves survival rates for glioma patients.
How similar studies have performed: Previous clinical trials have shown that tumor vaccines can improve the prognosis of glioma patients, indicating a promising approach in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: The patients with glioma patients/non-tumor patients (hemorrhagic stroke, ischemic stroke, and traumatic brain injury) in the Department of Neurosurgery of Huashan Hospital Affiliated to Fudan University who meet the following three conditions can be enrolled: 1. They were no age limit, male and female; 2. The pathological results of frozen section during operation were gliomas or non-tumor; 3. Tissue (6 mm \* 6 mm) can be used for cell sorting on the basis of not affecting clinical routine diagnosis; 4. Sign informed consent. Exclusion Criteria: Patients who meet any of the following criteria will not be included in this study: 1. Participants in other clinical trials; 2. Pregnant women.
Where this trial is running
Shanghai, Shanghai Municipality
- Huashan Hospital, Fudan University — Shanghai, Shanghai Municipality, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.