Triple Support Protein for midlife women's metabolic health
GLOW Study: A Randomized Trial to Evaluate the Effects of Triple Support Protein on Glucose, Lifestyle, and Overall Well-being in Women
This study will test whether taking Triple Support Protein powder every day for 4 weeks improves blood sugar control and overall well‑being in healthy women aged 30–60.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 30 Years to 60 Years |
| Sex | Female |
| Sponsor | University of North Carolina, Chapel Hill Academic / other |
| Locations | 1 site (Chapel Hill, North Carolina) |
| Trial ID | NCT07526571 on ClinicalTrials.gov |
What this trial studies
This is a single-site, randomized, double-blinded, placebo-controlled trial enrolling 40 healthy women aged 30–60 who are recreationally active. Participants receive a supervised acute dose, then take the assigned supplement or matched placebo daily for 4 weeks with weekly check-ins; baseline and end-of-study testing includes DXA, fasting labs, and standardized meal tests with 2‑hour glucose and insulin sampling. During the final 14 days participants wear a continuous glucose monitor to capture postprandial glucose AUC and insulin responsiveness, and body composition changes are measured by DXA. The supplement is a plant-based protein formula that includes creatine and fiber, and primary analyses use mixed-model ANOVA with α=0.05.
Who should consider this trial
Good fit: Healthy, recreationally active women aged 30–60 with BMI 18.5–40 kg/m² who are not pregnant or nursing and are not currently using whey protein or creatine would be ideal candidates.
Not a fit: Women who are pregnant or nursing, lactose intolerant, already taking whey protein or creatine, or who have underlying metabolic disease may not benefit or are excluded from this protocol.
Why it matters
Potential benefit: If successful, the supplement could offer a short-term, non-drug way to improve post-meal glucose control, support muscle, and boost well-being in midlife women.
How similar studies have performed: Prior research on protein, creatine, and fiber individually has shown modest improvements in postprandial glucose control and muscle support, but combined triple-ingredient supplements like this have limited direct evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Females aged 30-60 years. * BMI 18.5-40 kg/m\^2. * Recreationally active (≥30 min/wk moderate intensity exercise). * Healthy and free from disease per health history questionnaire. * Willing to abstain from caffeine, tobacco, and alcohol for 24 hours before testing days. Exclusion Criteria: * Currently supplementing whey protein. * Pregnant or nursing. * Lactose intolerant. * Currently using creatine monohydrate. * Severe hearing or speech impairment or inability to speak English
Where this trial is running
Chapel Hill, North Carolina
- Department of Exercise and Sport Science, Applied Physiology Laboratory — Chapel Hill, North Carolina, United States (Recruiting)
Study contacts
- Principal investigator: Abbie Smith-Ryan — University of North Carolina
- Study coordinator: Abbie Smith-Ryan
- Email: aplresearch@unc.edu
- Phone: 919-962-1663
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.