Treatment options for ovarian endometrioma
Official title: Endometrioma Sclerotherapy and Ovarian Preservation: a Randomised Control Trial of Laparoscopic Sclerotherapy vs Traditional Excision of Endometrioma
Run by Chelsea and Westminster NHS Foundation Trust · NCT06775769 · Data updated 2026-11-12
This study is testing whether a new method using ethanol can treat ovarian endometriomas as well as or better than standard surgery, while also looking at how it affects women's fertility and symptoms over two years.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | Chelsea and Westminster NHS Foundation Trust Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | February 21, 2025 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 25, 2025 |
| Trial ID | NCT06775769 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18-40 with suspected ovarian endometriomas of 2cm or larger who are seeking surgical management for endometriosis.
✕Probably not a fit
Patients who are postmenopausal or have suspected malignancy will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of laparoscopic ethanol sclerotherapy compared to standard surgical excision for treating ovarian endometriomas. Participants will be randomly assigned to one of the two treatment groups, and their ovarian reserve will be assessed through serum anti-Müllerian hormone levels and antral follicle counts. Secondary outcomes include monitoring for endometrioma recurrence, symptom relief, and changes in inflammation over a follow-up period of 24 months. The study aims to provide insights into preserving ovarian function while managing endometriomas.
Why it matters
Potential benefit: If successful, this study could offer a less invasive treatment option that preserves ovarian function for women with endometriomas.
How similar studies have gone: Previous studies have shown promise in using sclerotherapy for endometriomas, but this specific approach is being evaluated for its effectiveness in preserving ovarian reserve.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female (XX genotype, assigned female at birth) * Age 18-40 * Finding of suspected uni- or bi-lateral ovarian endometrioma(ta) of ≥ 2cm on TVUSS and/or pelvic MRI scan (TVUSS, a uni- or multi-locular ovarian cystic lesion with low level echoes and diffuse homogeneous ground glass appearance; MRI any of, ovarian lesion hyperintense T1 without loss of signal on T1 fat-suppressed images, hypointense T2 exhibiting shading sign and/or T2 dark spot sign, variable restricted diffusion on DWI) * Appropriate to be listed for laparoscopic excision of endometrioma (Endometrioma ≥2cm, pain symptoms attributable to endometriosis where medical management is unsuccessful or unacceptable to the patient, to facilitate ART) Exclusion Criteria: * Postmenopausal status * Suspicion of malignancy * Unable to undergo TVUSS * Declines to take part in the study * Unable to understand verbal or written information in English * Lack of capacity to consent at the point of recruitment * Known safeguarding issues
Where it's running
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Chelsea and Westminster NHS Foundation Trust
London, United Kingdom Recruiting
Study contacts
- Study coordinator: Sarah Bennet, BSc MBBS MRCOG
- Email: sarah.bennet25@imperial.ac.uk
- Phone: 07983980924
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Surgical options to preserve ovaries when treating endometriomas
This trial will see if different surgical methods for treating endometriomas help women who want to get pregnant have higher pregnancy and birth rates and fewer complications.
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Ethanol sclerotherapy for treating ovarian endometriomas
This study tests if a treatment using ultrasound-guided ethanol can help women with painful ovarian cysts shrink them and reduce their symptoms.
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Alcohol sclerotherapy for pelvic pain and quality of life in ovarian endometrioma
This trial will try ultrasound-guided alcohol sclerotherapy to see if it reduces pelvic pain and improves quality of life in women aged 18–45 with ovarian endometriomas compared with expectant management.
-
Understanding how the uterus absorbs fluid during early pregnancy
This study is trying to understand how the uterus absorbs fluid during early pregnancy in women, both with and without endometriosis, to learn more about the process.
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Using Estetrol and Drospirenone to Shrink Ovarian Endometriomas
This study is testing if a hormonal treatment called Estetrol and Drospirenone can help shrink painful ovarian cysts in women with endometriosis and improve their chances of getting pregnant.
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Laparoscopic drainage plus hormonal therapy for large ovarian endometriomas
This study will test whether laparoscopic cyst drainage followed by a GnRH agonist helps women of childbearing age with ovarian endometriomas 6 cm or larger have fewer recurrences and preserve ovarian reserve.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.