Treatment options for low blood pressure in individuals with spinal cord injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of both non-pharmacological and pharmacological treatments on individuals with spinal cord injury (SCI) who experience orthostatic hypotension. It aims to assess how these interventions impact hemodynamic responses, symptoms of autonomic dysreflexia, and overall levels of fatigue and comfort. The primary pharmacological intervention being tested is Midodrine Hydrochloride, which is known for its potential to raise blood pressure. Participants will be closely monitored to evaluate the effectiveness of these treatments in improving their quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* traumatic spinal cord injury
* at least 12 months post injury
* injury level of C1-T6
* AIS A, B or C
* non-ambulatory
* non-ventilator

Exclusion Criteria:

* Active psychiatric disorder
* Stroke or cerebrovascular disease
* Alzheimer's Disease or dementia
* Unmanaged cardiac arrhythmias
* Concurrent systemic, hepatic, or renal disease
* Suspected or diagnosed malignancy
* Neurological disease other than SCI
* Self-reported history of three or more symptomatic episodes of AD per day

Where it's running

• Kessler Foundation
  West Orange, New Jersey, United States Recruiting
• James J Peters VA Medical Center
  The Bronx, New York, United States Recruiting

Study contacts

• Study coordinator: Matt T Maher, MS
• Email: matthew.maher@va.gov
• Phone: 9733243588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.