Treatment options for complex aortoiliac disease

Comparison of Open Surgery, Hybrid and Endovascular Repair for Complex TASC C/D Aortoiliac Lesions

This study looks at different treatment options for people with complex aortoiliac disease to see which methods work best and are safest for them.

Quick facts

• Study type: Observational
• Enrollment: 900 (estimated)
• Ages: 18 Years to 100 Years
• Sex: All
• Sponsor: Clinical Centre of Serbia (Academic / other)
• Locations: 1 site (Belgrade)
• Trial ID: NCT06253312 on ClinicalTrials.gov

What this trial studies

This observational study evaluates the treatment approaches for patients with complex aortoiliac disease classified as TASC class C and D. It compares open surgical reconstruction, hybrid repair, and endovascular repair methods to determine their effectiveness and safety. The study aims to assess short, mid-, and long-term outcomes of these interventions in patients with a history of atherosclerotic peripheral arterial disease. By analyzing data from patients treated between January 2015 and January 2022, the study seeks to provide insights into the best management strategies for this challenging condition.

Who should consider this trial

Good fit: Ideal candidates for this study are adults over 18 years old with a history of atherosclerotic peripheral arterial disease.

Not a fit: Patients with acute limb ischemia, non-atherosclerotic disease origins, or limited life expectancy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help identify the most effective treatment options for patients with complex aortoiliac disease, potentially reducing morbidity and improving outcomes.

How similar studies have performed: Previous studies have shown promising results with endovascular techniques for similar conditions, indicating that this approach may be effective.

Eligibility criteria

Inclusion Criteria:

* All patients (over 18 years of age) with a history of atherosclerotic peripheral arterial disease treated between 1st January 2015 and 1st January 2022
* All management strategies will be included (endovascular, hybrid, and open)

Exclusion Criteria:

* Patients who are pregnant
* Patients who are under 18 years of age
* Patients who have acute limb ischemia or acute on chronic ischemia
* Non-atherosclerotic origin of disease: cyclist disease, trauma, dissection
* Patients who were treated in conservative manner
* Patients who underwent primary major amputation
* Patients with limited life expectancy (less than 2 years)

Where this trial is running

Belgrade

• Clinical Center of Serbia — Belgrade, Serbia (Recruiting)

Study contacts

• Study coordinator: Petar Zlatanovic, MD FEBVS

Conditions Peripheral Arterial Disease; Aortoiliac Occlusive Disease; Leriche Syndrome; Peripheral Vascular Disease; peripheral arterial disease; aortoiliac disease; TASC C,D; open surgery