Treatment of late-stage AIDS patients using mesenchymal stem cells

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the safety and efficacy of mesenchymal stem cell (MSC) treatment in patients with late-stage AIDS. It is a prospective, double-blind, randomized placebo-controlled trial that will involve administering MSCs to participants and comparing the outcomes with those receiving a saline placebo. The study will focus on measuring changes in CD4+ T lymphocyte counts and other immunological markers, as well as monitoring for any adverse effects. The goal is to better understand the therapeutic potential of MSCs in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Confirmed HIV infection, aged 18-65, both genders
2. CD4+T count less than 500 cells/ul at baseline.
3. No serious AIDS related events. 3. could understand and sign the informed consent form and comply with the requirements of this study.

4\. agree not to participate in other studies and not to receive other immunotherapies during the period of participation in this study

Exclusion Criteria:

1. have HBV/HCV/HDV/HEV infection, and the virological test is positive.
2. The viral load for CMV and EBV is more than 1000 copies/ML.
3. have HIV-2 infection.
4. have serious complications in organs including renal, circulatory, respiratory, digestive, endocrine, neural and immunological diseases and tumors.
5. received treatment of hormones or other immunosuppressive drugs for a long time.
6. with serious AIDS related or unrelated events.
7. received immunosuppressive drugs or systemic cytotoxic drugs for more than 3 months before recruiting
8. have poor compliance during treatment.
9. drug addiction within 6 months, or the urine drug test is positive
10. participate in other clinical trials currently
11. pregnant, breastfeeding, or have fertility requirements.
12. unable or unwilling to provide informed consents, or unable to comply with research requirements.
13. Other serious situations that may hinder clinical trials.

Where it's running

• Beijing 302 Hospital
  Beijing, China Recruiting
• Beijing YouAn Hospital
  Beijing, China Recruiting
• Shenzhen Third People's Hospital
  Shenzhen, China Recruiting
• The Fifth Hospital of Shijiazhuang
  Shijiazhuang, China Recruiting

Study contacts

• Principal investigator: Fu-Sheng Wang, Doctor — Beijing 302 Hospital
• Study coordinator: Fu-Sheng Wang, Doctor
• Email: fswang302@163.com
• Phone: 8610-13671005510

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.