Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the optimal use of L-asparaginase in treating acute lymphoblastic leukemia (ALL) in children and adolescents. It is a French multicentric cohort study that stratifies participants based on the type of ALL (B vs T lineage) and their anticipated risk. The study aims to evaluate the efficacy of different doses and administration methods of pegaspargase, a modified form of L-asparaginase, to improve treatment outcomes. By comparing these approaches, the trial seeks to enhance the therapeutic strategy for ALL in younger patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ALL L1 or L2
* B-lineage or T- lineage ALL

Exclusion Criteria:

* L3 (Burkitt's leukemia)
* Mixed Phenotype Acute Leukemia (WHO criteria).
* Infant ALL (age ≤ 365 days)
* Philadelphia (Ph)+/Breakpoint Cluster region (BCR)-Abelson (ABL) ALL

Where it's running

• Chu
  Amiens, France Recruiting
• Chu
  Angers, France Recruiting
• Chru
  Besançon, France Recruiting
• Chu
  Bordeaux, France Recruiting
• Chu
  Brest, France Recruiting
• Chu
  Caen, France Recruiting

Study contacts

• Study coordinator: André Baruchel, MD
• Email: andre.baruchel@aphp.fr
• Phone: +33 1 40 03 53 88

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.