Treatment for women with a specific type of PCOS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial focuses on female patients diagnosed with PCOS of phenotype D, characterized by menstrual cycle alterations and normal androgen levels. Participants will receive a dietary supplement containing Dioscorea extract, vitamin D, and alpha-lactalbumin for six months. The primary goal is to restore regular menstrual cycles and improve the ultrasound appearance of the ovaries, addressing the limitations of current treatments for this phenotype. The study aims to evaluate the efficacy of this natural approach in managing symptoms of PCOS phenotype D.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of PCOS of phenotype D, according to the Rotterdam Criteria and the EGOI-PCOS Criteria

Exclusion Criteria:

* Diagnosis of PCOS of phenotype A, B or C, according to the Rotterdam Criteria and the EGOI-PCOS Criteria
* Hormonal treatments;
* Treatments with inositol or other insulin sensitizers (such as metformin);
* Insulin resistance or pre-diabetes condition
* BMI \> 30
* Endocrinological alterations
* Chronic pharmacological therapies
* Major pathological conditions (e.g. tumors or autoimmune diseases)

Where it's running

• Alma Res Fertility Center
  Rome, Ita, Italy Recruiting

Study contacts

• Study coordinator: Cesare Aragona
• Email: aragonacesare@gmail.com
• Phone: +39 348 4043527

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ovarian drilling via vNOTES laparoscopy for PCOS patients

  This study tests whether drilling the ovaries using vNOTES laparoscopy can help women with PCOS who did not respond to first-line medicines.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT07923552

• PMOS and Sleep Apnea: A Pilot Look at Mitochondrial Function

  In women with PMOS, this pilot study tests whether sleep apnea treatment with CPAP improves mitochondrial function in leg muscle tissue.

  Recruiting University of Chicago · Chicago, Illinois · NCT07871149

• Lean Beef as Part of a Healthy Meal Plan for Adolescent Girls with PCOS/PMOS

  This pilot study tests a lean beef–based meal plan to see if it improves blood sugar control and diet quality in adolescent girls with PCOS/PMOS.

  Recruiting Texas A&M University · College Station, Texas · NCT07780188

• Inositol and Metformin with Mediterranean or Low-Carb Diets in Women with PCOS

  This trial tests whether adding inositol, metformin, or folic acid to either a Mediterranean or a low-carbohydrate diet helps women with PCOS and insulin resistance lose weight and improve metabolic markers.

  Recruiting Dicle University · Diyarbakır, Diyarbakır · NCT07770711

• Fecal microbiota transplantation for overweight women with PMOS undergoing embryo transfer

  We are testing if oral FMT capsules are safe and can improve pregnancy outcomes for overweight/obese women with PMOS undergoing frozen embryo transfer.

  Recruiting Shanghai Changzheng Hospital · Shanghai, Shanghai Municipality · NCT07746635

• Glp-1/FGF21 dual agonist for PCOS treatment

  This study tests a GLP-1/FGF21 dual agonist to see if it helps women with PCOS by improving weight, hormones, and menstrual health.

  Recruiting Phase 2 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07616037

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.