Treatment for murine and scrub typhus infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial focuses on evaluating the effectiveness of doxycycline and azithromycin in treating murine typhus and scrub typhus, two infectious diseases caused by rickettsial bacteria. Participants will be adults who test positive for these infections and agree to stay in the hospital for at least 36 hours for treatment and follow-up. The study aims to improve diagnosis and treatment options for these diseases, which have significant mortality rates if left untreated. The trial is conducted at the Lao-Oxford-Mahosot Hospital and Vientiane Provincial Hospital in Laos.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age above or equal 18 years
* Able to take oral medication
* Rapid test positive for murine typhus or scrub typhus
* Agrees to stay in hospital for at least 36 hours and to attend for scheduled follow up visits
* Written informed consent to participate in the study
* A negative urinary pregnancy test for all women of child-bearing age

Exclusion Criteria:

* Pregnancy or breast feeding
* Previous allergic reaction to doxycycline or azithromycin
* Received more than one dose of chloramphenicol, doxycycline, tetracycline, fluoroquinolones, rifampicin or azithromycin during this hospital admission or more than one dose of any of these drugs in the week before admission
* Contraindication to doxycycline: severe hepatic impairment, known SLE
* Contraindication to azithromycin: sever hepatic impairment
* Severe typhus defined as the presence of one or more of the following:

  1. Reduced level of consciousness
  2. Clinical jaundice
  3. Shock (BP systolic \<80 mmHg)
  4. Unable to take oral medication
  5. Radiological evidence of pneumonia
  6. Clinical evidence for meningitis/encephalitis or the need of LP
  7. Alternative diagnosis confirmed that explains the presenting symptoms
  8. Any other syndrome which in the opinion of the admitting doctor constitutes severe typhus (reason must be stated)

Where it's running

• Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)
  Vientiane, Vientaine, Laos Recruiting
• Vientiane Provincial Hospital
  Muang Phon-Hong, Vientiane Province, Laos Recruiting

Study contacts

• Principal investigator: Weerawat Phuklia, PhD — Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
• Study coordinator: Weerawat Phuklia, PhD
• Email: weerawat@tropmedres.ac
• Phone: +8562056581365

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• International collaboration to collect information on adults hospitalized with acute infections

  Researchers will collect health information and biological samples from adults hospitalized with acute infections to see how these infections start, progress, and respond to care.

  Recruiting at 55 sites University of Minnesota · Tucson, Arizona and 55 other locations · NCT07069400

• Pharmacogenomics to improve voriconazole dosing for fungal infections

  This trial will test whether using a patient's CYP2C19 genotype with Bayesian dosing software helps get voriconazole levels into the therapeutic range by Day 8 for people with fungal infections, including those with blood cancers.

  Recruiting at 7 sites Phase 2 The University of Queensland · Seattle, Washington and 6 other locations · NCT06510699

• Survey to assess eligibility for infectious disease clinical trials

  This study is trying to find out if people are eligible to join clinical trials for infectious diseases like HIV and vaccines by having them fill out a survey about their health and background.

  Recruiting Brooklyn Clinical Research · Brooklyn, New York · NCT06492187

• L-citrulline to reduce complications in hospitalized young children with fever

  This trial will test whether giving L-citrulline versus placebo to hospitalized children aged 1 month to under 5 years who have a moderate-to-high bedside sTREM-1 risk result can reduce death and serious complications.

  Recruiting at 2 sites Barcelona Institute for Global Health · Harar and 1 other locations · NCT06426147

• Rapid suPAR blood test to help triage febrile young children

  This study will test whether adding a quick suPAR point-of-care blood test to standard IMCI triage helps health workers better spot children aged 2–59 months with fever who need admission or referral.

  Recruiting at 2 sites Barcelona Institute for Global Health · Lambaréné, Moyen-Ogooué Province and 1 other locations · NCT06422338

• Investigating genetic factors in severe infections

  This study is trying to find out if certain genes make some people more likely to get severe infections than others by looking at patients with rare and serious infections.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Paris, Île-de-France Region · NCT06102070

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.