Treatment for exercise-induced laryngeal obstruction
Official title: Exercise Induced Laryngeal Obstruction; a Randomized Controlled Treatment Trial
Run by Haukeland University Hospital · NCT04620343 · Data updated 2026-11-12
This study is testing different treatment options for young people with exercise-induced breathing problems to see which ones help them breathe better during physical activity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | Haukeland University Hospital Academic / other |
| Locations | 1 site (Bergen, Vestland) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | December 31, 2023 |
| Study ends | December 31, 2036 |
| Registry record updated | August 16, 2022 |
| Trial ID | NCT04620343 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are young individuals diagnosed with EILO who experience significant respiratory complaints and are seeking treatment.
✕Probably not a fit
Patients with breathing problems caused by conditions other than EILO or those with well-controlled asthma may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates treatment options for exercise-induced laryngeal obstruction (EILO), a condition that causes breathing difficulties during physical activity in young individuals. Patients diagnosed with EILO will be randomized into four treatment groups, each receiving different combinations of breathing advice, inspiratory muscle training, and speech therapy. The goal is to provide evidence-based information on effective interventions for EILO, which has not been thoroughly validated through randomized controlled trials. The study will be conducted at Haukeland University Hospital, where patients will undergo continuous laryngeal visualization during high-intensity exercise to assess their condition.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatment options for young patients suffering from EILO, improving their exercise tolerance and quality of life.
How similar studies have gone: While there is empirical data suggesting positive responses to treatment for EILO, this study aims to fill the gap in randomized controlled trials, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * EILO with CLE score at peak exercise graded as ≥ 2 at glottic or supraglottic level and * Respiratory complaints to an extent that the patient wants further treatment and follow-up. Exclusion Criteria: * Breathing problems caused by disorders other than EILO or well controlled asthma. * Perceived to be unable to perform repeated maximal cardiopulmonary treadmill exercise tests, or failing to accept the procedures required for repeated successful CLE tests, or unable to perform any of the other examinations required by the protocol. * Abnormal anatomy at rest in the laryngeal region or the upper airways. * Age below 12 years
Where it's running
-
Haukeland University Hospital, Children and Youth Clinic
Bergen, Vestland, Norway Recruiting
Study contacts
- Principal investigator: Hege H Clemm, MD, PhD — Haukeland University Hospital
- Study coordinator: Hege H Clemm, MD, PhD
- Email: hege.synnove.havstad.clemm@helse-bergen.no
- Phone: 004792606661
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Nicotinamide Riboside by Mouth for Early Alzheimer’s Disease (2-Year Trial)
This study tests whether taking nicotinamide riboside every day for 24 months can slow progression in adults with early Alzheimer’s disease.
-
Effect of a Liberal Fasting Regime on Preoperative Gastric Volume Measured by Ultrasound
This study tests whether letting adults drink small amounts of clear liquid up to when they’re called for surgery (sip-to-send) is not worse than the standard fasting for keeping the stomach empty before general anesthesia.
-
eCardiacRehab: a home-based, patient-centered cardiac rehab program
This trial tests a hybrid home-based cardiac rehabilitation program to see if it reduces cardiovascular deaths and ED visits while improving quality of life for adults with CAD after PCI, compared with usual care.
-
D-SPARK: D‑Serine to modify Parkinson's progression
This trial will test whether taking D‑serine can slow Parkinson's progression in people diagnosed within five years.
-
Big Five daily actions program adapted for Norway
This trial will test whether a brief Norwegian program encouraging five daily actions helps people in Norway with mild-to-moderate anxiety or depression compared with a gratitude activity or no treatment.
-
Behavioral therapy plus GLP-1 medicines for binge eating and weight in people with obesity
This project will try adding GLP-1 medications to a lifestyle program with CBT-E to see if they reduce binge eating and help adults with obesity lose weight and cope better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.