Treatment for advanced gastrointestinal cancers using MK-2870 with or without chemotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical study investigates the effectiveness of sacituzumab tirumotecan (MK-2870) alone or in combination with chemotherapy for patients with advanced or unresectable gastrointestinal cancers, specifically colorectal cancer, pancreatic ductal adenocarcinoma, and biliary tract cancer. The study aims to assess the safety and tolerability of the treatment, as well as the response rate of the cancer to the intervention. Participants will have previously received therapy for their cancer and must have recovered from any side effects before joining the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

* Has one of the following cancers:

  * Unresectable or metastatic colorectal cancer and has received prior therapy for the cancer
  * Advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) and has received prior therapy for the cancer
  * Advanced and/or unresectable biliary tract cancer (BTC) and has received prior therapy for the cancer
  * Advanced and/or unresectable BTC and has not received prior therapy for the cancer
* For participants who have received prior therapy for cancer: Has recovered from any side effects due to previous cancer treatment

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

* History of severe eye disease
* For participants who have received prior therapy for cancer: Received prior systemic anticancer therapy including investigational agents within 4 weeks before starting study intervention
* History of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids, has current pneumonitis/ILD, or has suspected ILD or pneumonitis that cannot be ruled out by standard diagnostic assessments at Screening

Where it's running

• UCLA ( Site 0317)
  Los Angeles, California, United States Recruiting
• University of Colorado Anschutz Medical Campus ( Site 0299)
  Aurora, Colorado, United States Recruiting
• University of Colorado Anschutz Medical Campus ( Site 0325)
  Aurora, Colorado, United States Recruiting
• University of Colorado Anschutz Medical Campus ( Site 0326)
  Aurora, Colorado, United States Recruiting
• University of Florida College of Medicine ( Site 0281)
  Gainesville, Florida, United States Recruiting
• Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0327)
  Mineola, New York, United States Recruiting

+5 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Toll Free Number
• Email: Trialsites@msd.com
• Phone: 1-888-577-8839

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.