Treatment for acute stroke with carotid artery issues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effectiveness of carotid artery stenting combined with endovascular thrombectomy in patients suffering from acute anterior circulation strokes with concurrent high-grade stenosis or occlusion of the internal carotid artery. It is a phase III, multi-centre, randomized, open-label trial that aims to compare functional outcomes at 90 days between patients receiving stenting and those undergoing thrombectomy alone. The study will enroll 458 adult patients across 10-12 high-volume stroke centers in Canada, with a follow-up period of up to one year.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Acute ischemic anterior circulation stroke eligible for endovascular therapy according to local guidelines, with or without prior intravenous thrombolysis:

  * Occlusion of the carotid terminus, M1 or M2 segments of the middle cerebral artery (MCA)
  * A neurological deficit judged to be disabling by the patient and/or treating physician
  * Any acute imaging judged by the treating physician to demonstrate salvageable brain tissue possibly amenable to EVT
  * Groin puncture within 24-hours of onset or last known normal
* Tandem ipsilateral high-grade (≥70%) cervical internal carotid artery (ICA) stenosis or occlusion of presumed atherosclerotic etiology on initial non-invasive vascular imaging
* Informed consent from patient or surrogate or deferral of consent, according to local ethics policies

Exclusion Criteria:

* Pre-existing neurological impairment (modified Rankin score ≥3)
* Any underlying disease or condition making protocol adherence and/or 3-month follow-up unlikely
* Any known contra-indication to EVT, angioplasty/stenting, or antiplatelet therapy
* Tandem ipsilateral high-grade (≥70%) cervical internal carotid artery (ICA) stenosis or occlusion NOT confirmed on conventional angiography
* Ipsilateral ICA stenosis or occlusion attributable to clinically or radiologically confirmed arterial dissection
* Isolated cervical carotid occlusion without intracranial occlusion
* Pregnancy

Where it's running

• Centre Hospitalier de l'Université de Montréal
  Montreal, Quebec, Canada Recruiting

Study contacts

• Principal investigator: Alexandre Y Poppe, MD CM — Centre hospitalier de l'Université de Montréal (CHUM)
• Study coordinator: Alexandre Y Poppe, MD CM
• Email: alexandre.poppe.med@ssss.gouv.qc.ca
• Phone: 5148908000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Managing asymptomatic carotid stenosis to prevent strokes

  This study looks at whether surgery to clear blocked neck arteries can help older patients with no symptoms avoid strokes.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT06882954

• Effectiveness of a new neurorehabilitation technology for stroke recovery

  This study is testing a new rehabilitation technology that uses robots and virtual reality to see if it can help stroke patients recover better than regular therapy.

  Recruiting Neurotechnika · Samara, Samara Oblast · NCT06753006

• Carotid artery stenting during treatment of acute stroke

  This study is testing if adding carotid artery stenting during a stroke treatment can help improve blood flow to the brain and lower the chances of having another stroke for patients with blocked carotid arteries.

  Recruiting Phase 3 University Medical Center Groningen · Groningen · NCT06511089

• Music therapy after stroke

  This trial tests whether adding music therapy to standard care helps stroke patients sleep better and feel less anxious or depressed while in the hospital.

  Recruiting Universidad de Granada · Granada, Granada · NCT07899034

• Will GFAP in the blood after carotid endarterectomy predict neurological problems?

  This study tests whether blood GFAP levels before and after carotid endarterectomy relate to postoperative neurological issues in adults.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa, Bursa · NCT07843979

• Endovascular therapy plus standard care vs standard care alone for distal and medium vessel strokes

  In people with acute ischemic stroke due to distal or medium vessel blockages, this study tests whether adding endovascular treatment to the usual medical care helps improve outcomes compared with medical care alone.

  Recruiting Hospital Universitari Vall d'Hebron Research Institute · Barcelona, Barcelona · NCT07843797

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.