Treating post-dural puncture headache with theophylline, sumatriptan, or gabapentin

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults aged 21–50 with clinically diagnosed post-dural puncture headache and a pain score of at least 5 are enrolled at Tanta University and given one of three medications (theophylline, sumatriptan, or gabapentin). The study compares how well each drug reduces headache severity and records side effects to compare safety. Treatments are given per protocol and patients are followed for clinical response and adverse events. Outcomes focus on pain relief magnitude and tolerability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 21 to 50 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status ≤ II.
* Patient's selection for this study will be based on clinical diagnosis suggesting post-dural puncture headache (PDPH) based on the International Headache Society criteria.
* Patients with numeric rating scale (NRS) of ≥ 5.

Exclusion Criteria:

* Pregnant women.
* History of; chronic headache, cluster headache, migraine, convulsions, cerebrovascular accident, and previous neurological diseases.
* Signs of meningismus.
* Dysrhythmia.
* Hypertension.
* Ischemic heart disease.
* Hyperthyroidism.
* Peripheral vascular disease (ischemic colitis).
* Liver or renal impairment.
* Use of selective serotonin reuptake inhibitors.
* Use of ergotamine derivatives in the past 24 hours.
* Use of monoamine oxidase inhibitors in the last 2 weeks.
* Use of any kind of opiates.
* Allergy to the study medications and any contraindication of oral intake.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Asmaa R Eid, MSc
• Email: asmaaragabeid@gmail.com
• Phone: 00201026382543

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.