Transplanting ovarian tissue to restore fertility after cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and efficacy of autologous ovarian tissue transplantation in women diagnosed with primary ovarian insufficiency following chemotherapy or radiation. Participants will have previously cryopreserved ovarian cortical tissue thawed and surgically transplanted. The study includes a series of follow-up assessments during the first two years post-transplantation, along with annual surveys thereafter to monitor outcomes. The aim is to evaluate the potential for restoring ovarian function and fertility in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Previously cryopreserved ovarian tissue
* Ovarian insufficiency and/or candidate for pregnancy
* Good health
* Oncologist's clearance

Exclusion Criteria:

* Patients considered to be high risk for surgical complications
* Women with contraindication for pregnancy if goal is to achieve pregnancy
* Women positive for the BRCA mutations
* Women with a history of leukemia, ovarian cancer or a cancer that likely involved ovaries at the time of ovarian tissue collection
* Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
* Current pregnancy

Where it's running

• Magee-Womens Hospital
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Kyle Orwig, PhD — University of Pittsburgh/University of Pittsburgh Medical Center
• Study coordinator: Jennifer Anglin
• Email: fertilitypreservation@upmc.edu
• Phone: 412-641-7475

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.