Transfusion of packed red blood cells during cardiac arrest
A Single-center, Randomized, Placebo Controlled Pilot Study of Packed Red Blood Cell Transfusion During Prolonged Adult In-hospital Cardiac Arrest
This study is testing if giving packed red blood cells during cardiac arrest can help improve oxygen flow to the brain and other vital organs during CPR, and how it affects survival and recovery.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | NYU Langone Health Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT06462027 on ClinicalTrials.gov |
What this trial studies
This pilot interventional study aims to evaluate the feasibility of administering packed red blood cells (PRBC) during cardiac arrest to enhance oxygen delivery to vital organs during cardiopulmonary resuscitation (CPR). The study will assess the effects of PRBC transfusion on cerebral oxygenation, end tidal carbon dioxide levels, return of spontaneous circulation, survival rates, and neurological outcomes at various time points post-cardiac arrest. Participants will receive either one or two units of PRBC or saline as part of the intervention.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 85 who have experienced prolonged, non-trauma-related in-hospital cardiac arrest requiring CPR for at least 10 minutes.
Not a fit: Patients who are under 18 or over 85 years old, have DNR/DNI orders, or have experienced trauma-related cardiac arrest will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve survival rates and neurological outcomes for patients experiencing cardiac arrest.
How similar studies have performed: While the approach of using PRBC during cardiac arrest is novel, similar studies exploring blood product transfusion in critical care settings have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients, age ≥18 and \<85 years * Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes Exclusion Criteria: * Age \<18 years old * Age \> 85 years old * Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate) * Patients admitted to the hospital with a cardiac arrest arising from trauma * Patients who achieve return of spontaneous circulation within 10 minutes of CPR * Inability to start study product administration within 20 minutes of cardiac arrest onset * Prisoners * Women who are known to be pregnant * Patients with a history of RBC antibodies or positive antibody screen prior to enrollment in the study, unless previously cross-matched units are available for transfusion. * Patients with ultrasound evidence of right ventricular dilatation at time of CA * Patients with known prior objection to receipt of blood products. * Patients for whom administration of additional fluid volume is contraindicated (as determined by physician responsible for care) * Physician objection based on concern that intervention would interfere with patient care plan
Where this trial is running
New York, New York
- NYU Langone Health — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Sam Parnia, MD — NYU Langone Health
- Study coordinator: Anelly Gonzales
- Email: resuscitationlab@nyulangone.org
- Phone: 646-501-6923
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.