Tranexamic acid use for heavy bleeding after cesarean delivery
Official title: A Retrospective Analysis of the Longitudinal Pattern of Tranexamic Acid Administration in Parturients Undergoing Cesarean Delivery Complicated by Postpartum Hemorrhage
Run by Mahidol University · NCT07278037 · Data updated 2026-11-12
This study will test whether wider use of tranexamic acid for heavy postpartum bleeding during cesarean delivery is linked to better outcomes for mothers and babies.
Quick facts
| Study type | Observational |
|---|---|
| Sex | Women only |
| Enrollment | 648 (estimated) |
| Sponsor | Mahidol University Academic / other |
| Locations | 1 site (Bangkoknoi, Bangkok) |
| Status | Recruiting |
| Started | December 1, 2025 |
| Main results expected | March 31, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | December 22, 2025 |
| Trial ID | NCT07278037 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women who experienced primary postpartum hemorrhage of 1,000 ml or more during cesarean delivery with complete anesthetic records at Siriraj Hospital.
✕Probably not a fit
Women with gestational age under 24 weeks, those who received tranexamic acid before delivery, cases with blood loss under 1,000 ml, or lacking anesthetic records would not be included and thus would not benefit from this analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, retrospective analysis of cesarean deliveries complicated by primary postpartum hemorrhage at Siriraj Hospital, Mahidol University. Investigators will measure how often tranexamic acid (TXA) has been used over recent years and calculate the growth rate of its use after publication of major guidelines. The study will compare obstetric and perinatal outcomes—such as need for blood transfusion, additional surgical interventions, and neonatal status—between cases that did and did not receive TXA, using hospital records and anesthetic charts. Patients with gestational age <24 weeks, antepartum TXA exposure, missing anesthetic records, or blood loss <1,000 ml are excluded from analysis.
Why it matters
Potential benefit: If increased TXA use is associated with better outcomes, the findings could support broader, timely use of TXA to reduce bleeding-related complications and deaths after cesarean delivery.
How similar studies have gone: The large WOMAN randomized trial (2017) showed a 31% reduction in PPH-related mortality when TXA was given within three hours, and subsequent implementation reports have documented increased TXA adoption.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Patients underwent cesarean delivery with primary postpartum hemorrhage Exclusion Criteria: 1. Gestational age at less than 24 weeks 2. Absence of the anesthetic record 3. Received tranexamic acid in the antepartum period 4. Blood loss less than 1,000 ml
Where it's running
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Siriraj Hospital
Bangkoknoi, Bangkok, Thailand Recruiting
Study contacts
- Principal investigator: Patchareya Nivatpumin, M.D. — Siriraj Hospital
- Study coordinator: Patchareya Nivatpumin, M.D.
- Email: patcahreya.niv@mahidol.ac.th
- Phone: +66896662187
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.