Training to improve executive functioning in older adults with HIV
Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults With HIV
This study is testing whether a special training program can help older adults with HIV improve their thinking skills and daily activities.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT05598047 on ClinicalTrials.gov |
What this trial studies
This study focuses on cognitive aging in people with HIV, particularly those experiencing HIV-Associated Neurocognitive Disorder (HAND). It aims to assess the effectiveness of a 20-hour Executive Functioning Training program designed to enhance cognitive performance and everyday functioning in older adults. Participants will undergo a baseline assessment to classify their HAND status before being randomly assigned to either the training group or a no-contact control group. The study will evaluate changes in cognitive function through pre- and post-training assessments.
Who should consider this trial
Good fit: Ideal candidates are English-speaking adults aged 40 and older with a diagnosis of HAND who can commit to in-person participation for approximately 12 weeks.
Not a fit: Patients living more than 60 miles from the center or those with significant neuromedical comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this training could significantly improve cognitive functioning and quality of life for older adults living with HIV.
How similar studies have performed: Other studies have shown promise in cognitive training for improving cognitive function in similar populations, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants (men \& women) must be 40+ years * English speaking, * Willing to meet in person * Has time to participate for \~12 weeks Exclusion Criteria: * Participants living beyond 60 miles away from the center * Participants living in unstable housing (e.g., halfway house) * Participants with significant neuromedical comorbidities (e.g., schizophrenia) * Participants with other conditions (e.g., legally blind/deaf, currently undergoing radiation or chemotherapy, or a history of significant brain trauma, diagnosed with COVID-19 over the past 3 months) that could impact cognitive functioning or testing. * Participants who have received cognitive training within the past three years
Where this trial is running
Birmingham, Alabama
- UAB School of Nursing — Birmingham, Alabama, United States (Recruiting)
Study contacts
- Study coordinator: David E Vance
- Email: devance@uab.edu
- Phone: 2059343789
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.