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Clinical trial No longer in our active list Phase 2 Interventional Ages 40 and up

Training to improve executive functioning in older adults with HIV

Official title: Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults With HIV

Run by University of Alabama at Birmingham · NCT05598047 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study is testing whether a special training program can help older adults with HIV improve their thinking skills and daily activities.

Quick facts

PhasePhase 2
Study typeInterventional
Ages40 Years and up
SexAll
Enrollment120 (estimated)
SponsorUniversity of Alabama at Birmingham
Academic / other
Drugs / interventionschemotherapy, radiation
Locations1 site (Birmingham, Alabama)
Trial IDNCT05598047 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking adults aged 40 and older with a diagnosis of HAND who can commit to in-person participation for approximately 12 weeks.

Probably not a fit

Patients living more than 60 miles from the center or those with significant neuromedical comorbidities may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on cognitive aging in people with HIV, particularly those experiencing HIV-Associated Neurocognitive Disorder (HAND). It aims to assess the effectiveness of a 20-hour Executive Functioning Training program designed to enhance cognitive performance and everyday functioning in older adults. Participants will undergo a baseline assessment to classify their HAND status before being randomly assigned to either the training group or a no-contact control group. The study will evaluate changes in cognitive function through pre- and post-training assessments.

Why it matters

Potential benefit: If successful, this training could significantly improve cognitive functioning and quality of life for older adults living with HIV.

How similar studies have gone: Other studies have shown promise in cognitive training for improving cognitive function in similar populations, suggesting potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Participants (men \& women) must be 40+ years
* English speaking,
* Willing to meet in person
* Has time to participate for \~12 weeks

Exclusion Criteria:

* Participants living beyond 60 miles away from the center
* Participants living in unstable housing (e.g., halfway house)
* Participants with significant neuromedical comorbidities (e.g., schizophrenia)
* Participants with other conditions (e.g., legally blind/deaf, currently undergoing radiation or chemotherapy, or a history of significant brain trauma, diagnosed with COVID-19 over the past 3 months) that could impact cognitive functioning or testing.
* Participants who have received cognitive training within the past three years

Where it's running

  • UAB School of Nursing
    Birmingham, Alabama, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Aging 2413Cognitive Function Abnormal 2Cognitive Performance 8Cognitive Training 2University of Alabama at Birmingham 1432
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.