Tracking iron distribution in the body after intravenous iron infusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate how intravenous iron infusion affects tissue iron levels over time in patients with iron deficiency. Participants will receive their iron infusion as part of standard care and will undergo a series of MRI scans at specified intervals to measure iron uptake in various tissues. Blood samples will also be collected to assess hematological and iron parameters. The study is conducted at the Oxford Centre for Clinical Magnetic Resonance Research, utilizing established MRI techniques to accurately track iron distribution.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participant is willing and able to give informed consent for participation in the study.
* Aged 18 years or above.
* Anaemia (haemoglobin less than 120g/L for women and less than 130g/L for men) and/or confirmed iron deficiency (ferritin less than 100mcg/L and/or transferrin saturation less than 20%).
* Scheduled to receive intravenous iron for correction of iron deficiency.

Exclusion Criteria:

* Any MRI incompatible implants (e.g. cardiac, neuro, ocular implants, surgical clips, aneurysm clips, shrapnel/bullets)
* Pregnant or lactating participant
* Acute decompensated heart failure
* Unstable clinical status
* Any other medical conditions which would influence the reliability of the study results determined by the investigators.
* Any other contraindication to MRI to be confirmed by the qualified MRI operator, e.g. tattoos containing traces of metal.

Where it's running

• Oxford Centre for Clinical Magnetic Resonance Research (OCMR)
  Oxford, Oxfordshire, United Kingdom Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Iron status prediction in elderly with inflammation

  This study tests a model to tell true iron deficiency from inflammation-related anemia in people aged 75 and older who are hospitalized with inflammation.

  Recruiting Centre Hospitalier Régional d'Orléans · Orléans, Loiret · NCT07739524

• Lactoferrin with low-dose iron to boost iron levels and aerobic fitness in active women

  We will test whether taking lactoferrin with a small daily dose of iron helps raise iron stores and improve aerobic performance in menstruating women with low ferritin.

  Recruiting Lindenwood University · Saint Charles, Missouri · NCT07546591

• AI-guided risk alerts to help doctors spot iron deficiency

  This trial tests whether an AI risk alert shown to clinicians after a CBC helps them detect iron deficiency more often in adult outpatients.

  Recruiting China Medical University Hospital · Taichung · NCT07394088

• Intravenous iron infusion after transcatheter aortic valve implantation for people with iron deficiency

  This trial will test whether an intravenous iron infusion after TAVI helps people aged 65 and older with severe aortic stenosis and iron deficiency feel better and walk farther.

  Recruiting Phase 4 Erasmus Medical Center · Rotterdam, South Holland · NCT07370688

• Intravenous iron to improve exercise capacity and quality of life in pulmonary hypertension

  This trial will test whether intravenous ferric carboxymaltose can improve exercise ability and quality of life in adults with pulmonary hypertension who have iron deficiency.

  Recruiting Phase 4 Ziekenhuis Oost-Limburg · Aalst and 6 other locations · NCT07359599

• Preoperative IV iron for teens having spinal fusion to correct scoliosis

  This trial will try giving a single IV iron infusion before spinal fusion to see if it helps 10–19-year-olds with scoliosis and low iron by reducing blood transfusions and improving recovery.

  Recruiting Phase 2/3 Columbia University · New York, New York · NCT07217873

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.