Tracking infections and inflammation in people with ME/CFS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

CHIIME is a prospective observational cohort enrolling adults with ME/CFS and healthy controls at Zuckerberg San Francisco General Hospital. Participants complete detailed interviews, clinical assessments, and serial biospecimen collection for high-quality biobanking. Samples are de-identified and used for molecular, immunologic, and physiological analyses to enable deep clinical phenotyping. The goal is to map biological signatures and clinical trajectories of ME/CFS over time to inform future diagnostic markers and interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Willing and able to provide written informed consent
* At least 18 years of age
* Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control)

Exclusion Criteria:

* Self reported or documented chronic anemia with hemoglobin \<9 g/dL
* Known HIV, hepatitis B, or hepatitis C infection
* Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)
* Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent
* Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent

Where it's running

• Zuckerberg San Francisco General Hospital
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Michael J. Peluso — University of California, San Francisco
• Study coordinator: Beatrice Program Manager
• Email: chiime@ucsf.edu
• Phone: (415) 502-2449

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.