Topical-Lingual Semaglutide for Obesity in Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a phase 4, interventional study evaluating a topical-lingual liquid emulsion of semaglutide against the tablet form and a placebo in adults with obesity or overweight. Participants will be randomized to receive the topical-lingual semaglutide, the Wegovy tablet, or placebo, with the goal of comparing weight loss, safety, and tolerability across groups. Pharmacokinetic data, including maximum serum concentration, will be collected to understand exposure for the different delivery methods. The study aims to establish proof-of-concept for topical-lingual delivery of metabolic hormones and its potential to impact weight management. Enrollment is limited to adults with BMI 30-45 without type 2 diabetes or certain thyroid/neoplasm conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Body Mass Index 30 to 45

Exclusion Criteria:

* Type 2 Diabetes Mellitus
* Multiple Endocrine Neoplasia Type 2
* Medullary thyroid cancer

Where it's running

• Clinical Research Institute of Minnesota
  Minneapolis, Minnesota, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.