Tools and markers to predict brain recovery after cardiac arrest
Official title: New Tools and Predictive Markers in the Prognosis of Hypoxic-ischemic Encephalopathy Following Cardiac Arrest
Run by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT07464938 · Data updated 2026-11-12
This will test whether combining advanced blood protein profiling with bedside brain ultrasound can better predict neurological recovery in adults admitted after out-of-hospital cardiac arrest.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Locations | 1 site (Brussels) |
| Status | Recruiting |
| Started | March 23, 2026 |
| Main results expected | April 1, 2028 |
| Study ends | April 1, 2028 |
| Registry record updated | March 27, 2026 |
| Trial ID | NCT07464938 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) admitted to the enrolling hospital after out-of-hospital cardiac arrest who are not transfers and who do not have pre-existing neurological disease are the ideal candidates.
✕Probably not a fit
Patients transferred from other hospitals or those with pre-existing neurological disease are excluded and would not participate or benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The project enrolls adults admitted after out-of-hospital cardiac arrest and combines advanced serum proteomic profiling with bedside cerebral ultrasound measures such as flow velocities and optic nerve sheath diameter. Participants receive routine post-arrest care while additional blood samples and ultrasound scans are collected at predefined times. Investigators will integrate biomarker and ultrasound data with clinical information to build prediction models for neurological outcomes. The goal is to improve early prognostication and reduce uncertainty in decisions about life-sustaining therapies.
Why it matters
Potential benefit: If successful, this approach could give clinicians more accurate early information about brain recovery after cardiac arrest, helping guide treatment decisions and avoid premature withdrawal of life support.
How similar studies have gone: Biomarker-based prognostication and individual ultrasound measures have shown promise in prior work, but combining comprehensive proteomics with cerebral ultrasound for outcome prediction is relatively novel and not yet validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients 18-year-old with OHCA admitted to our hospital receiving routine care. Exclusion Criteria: * Patients transferred from other hospitals for OHCA management * Patients with pre-existent neurological disease.
Where it's running
-
Cliniques universitaires Saint-Luc
Brussels, Belgium Recruiting
Study contacts
- Study coordinator: Pasquale Scoppettuolo, MD
- Email: pasquale.scoppettuolo@saintluc.uclouvain.be
- Phone: +3227618176
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.