Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Tools and markers to predict brain recovery after cardiac arrest

Official title: New Tools and Predictive Markers in the Prognosis of Hypoxic-ischemic Encephalopathy Following Cardiac Arrest

Run by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT07464938 · Data updated 2026-11-12

This will test whether combining advanced blood protein profiling with bedside brain ultrasound can better predict neurological recovery in adults admitted after out-of-hospital cardiac arrest.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment50 (estimated)
SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain
Academic / other
Locations1 site (Brussels)
StatusRecruiting
StartedMarch 23, 2026
Main results expectedApril 1, 2028
Study endsApril 1, 2028
Registry record updatedMarch 27, 2026
Trial IDNCT07464938 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) admitted to the enrolling hospital after out-of-hospital cardiac arrest who are not transfers and who do not have pre-existing neurological disease are the ideal candidates.

Probably not a fit

Patients transferred from other hospitals or those with pre-existing neurological disease are excluded and would not participate or benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project enrolls adults admitted after out-of-hospital cardiac arrest and combines advanced serum proteomic profiling with bedside cerebral ultrasound measures such as flow velocities and optic nerve sheath diameter. Participants receive routine post-arrest care while additional blood samples and ultrasound scans are collected at predefined times. Investigators will integrate biomarker and ultrasound data with clinical information to build prediction models for neurological outcomes. The goal is to improve early prognostication and reduce uncertainty in decisions about life-sustaining therapies.

Why it matters

Potential benefit: If successful, this approach could give clinicians more accurate early information about brain recovery after cardiac arrest, helping guide treatment decisions and avoid premature withdrawal of life support.

How similar studies have gone: Biomarker-based prognostication and individual ultrasound measures have shown promise in prior work, but combining comprehensive proteomics with cerebral ultrasound for outcome prediction is relatively novel and not yet validated.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients 18-year-old with OHCA admitted to our hospital receiving routine care.

Exclusion Criteria:

* Patients transferred from other hospitals for OHCA management
* Patients with pre-existent neurological disease.

Where it's running

  • Cliniques universitaires Saint-Luc
    Brussels, Belgium
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.