Titrated ciprofol anesthesia to prevent low blood pressure in older adults having laparoscopic abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial enrolls patients aged 65 and older scheduled for elective laparoscopic abdominal surgery and compares titrated ciprofol-based anesthesia to standard dosing. Anesthetic dosing will be adjusted to predefined hemodynamic endpoints with invasive arterial blood pressure monitoring to guide titration. The primary focus is intraoperative hypotension, with secondary measures including postoperative recovery outcomes. Patients with severe liver or kidney failure, uncontrolled hypertension, preoperative vasopressor needs, or major cognitive/psychiatric disorders are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥65 years, scheduled for elective laparoscopic abdominal surgery
* American Society of Anesthesiologists (ASA) physical status I-III
* Requirement for invasive arterial blood pressure monitoring

Exclusion Criteria:

* Participation in other clinical trials that may interfere with the intervention or outcomes of this study
* Severe hepatic or renal disease (GFR ≤30 mL/min/1.73 m², requirement for renal replacement therapy, or Child-Pugh class C liver function)
* Uncontrolled severe hypertension (preoperative SBP ≥180 mmHg or DBP ≥110 mmHg)
* Patients with severe mental disorders (such as schizophrenia), epilepsy, or Parkinson's disease, severe cognitive or intellectual impairment, severe visual or hearing impairments affecting assessment, or long-term alcohol abuse or use of sedative/analgesic medications;
* Known allergy to drugs used in this study
* Requirement for continuous vasopressor infusion before surgery, or intraoperative need for prolonged hemodynamic manipulation due to surgical factors
* Anticipated blood loss \>15% of estimated blood volume
* Expected surgical duration \<1 hours or \>6 hours
* Expected postoperative hospital stay \<72 hours

Where it's running

• Sixth Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting
• Sixth Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Not yet recruiting

Study contacts

• Study coordinator: Hong Bai, Doctoral student
• Email: bhong@mail.sysu.edu.cn
• Phone: +86 13480250519

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.