Timing of kidney replacement therapy in tumor lysis syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective, multicenter ICU study using data from French hospitals collected between 2013 and 2023 to compare early versus delayed initiation of renal replacement therapy (RRT) in patients with tumor lysis syndrome (TLS) and acute kidney injury (AKI). Investigators will extract clinical and laboratory data to classify timing of RRT and track renal function, RRT use, and mortality. The primary outcome is renal function at 30 days after ICU admission, with additional outcomes including 30-day and one-year mortality and ongoing dialysis dependence. The analysis aims to determine whether timing of RRT initiation is associated with better short- and longer-term renal outcomes in this specific population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged ≥18 years.
* Hospitalized in the ICU between January 1, 2013, and December 31, 2023.
* Diagnosed with a hematologic malignancy or solid tumor requiring chemotherapy.
* Diagnosed with TLS based on the presence of two or more biochemical criteria (e.g., hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalcemia) within 3 days before or 7 days after chemotherapy initiation.

Exclusion Criteria:

* Patient or family opposition to data collection for research purposes.
* Incomplete medical records that preclude data extraction.

Where it's running

• Hôpital Pellegrin
  Bordeaux, France Recruiting
• Hôpital la cavale blanche
  Brest, France Recruiting
• Hôtel-Dieu
  Nantes, France Recruiting
• CHR d'Orléans
  Orléans, France Recruiting
• CH de Pau
  Pau, France Recruiting
• Centre Urgences-Réanimations
  Rennes, France Recruiting

Study contacts

• Study coordinator: Arthur ORIEUX
• Email: arthur.orieux@chu-bordeaux.fr
• Phone: 05 56 70 56 79

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.