Time to Lose Consciousness With Remimazolam vs Propofol for Anesthetic Induction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 4 trial compares two intravenous drugs used to start general anesthesia in adults having elective laparoscopic cholecystectomy. Participants are randomly assigned to receive either remimazolam or propofol during induction, with standard monitoring and care throughout surgery. The trial records time to loss of consciousness, vital signs, and any adverse events during the induction period to assess hemodynamic stability and safety. By focusing on a single surgical procedure and controlled delivery, the study aims to reduce variability seen in prior comparisons. Automated delivery algorithms are used to manage drug administration to maintain consistency and safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 years or older.
* American Society of Anesthesiologists (ASA) physical status I, II or III.
* Scheduled to undergo elective laparoscopic cholecystectomy under Total Intravenous Anesthesia (TIVA).

Exclusion Criteria:

* Patients younger than 18 years or older than 60 years
* American Society of Anesthesiologists (ASA) physical status IV to V
* Body Mass Index (BMI) \< 17.5 kg/m² or \> 35 kg/m²
* Hemodynamically unstable patients
* Altered or impaired renal or hepatic function
* Neuromuscular disorders
* History of alcohol or drug dependence
* History of allergy or hypersensitivity to any of the anesthetic medications utilized in the protocol

Where it's running

• Hospital Univeritário da Universidade Federal de Sergipe
  Aracaju, Sergipe, Brazil Recruiting

Study contacts

• Principal investigator: Fabrício A Dias Antunes, MD, MSc, PhD — Universidade Federal de Sergipe
• Study coordinator: Gabriel M Figueiredo Mascarenhas, MD
• Email: gabrielfigueiredomascarenhas@gmail.com
• Phone: +5571987894554

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.