Pringle maneuver and later gallbladder problems after liver resection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter retrospective cohort study will extract clinical records from patients who underwent elective hepatectomy with gallbladder preservation between January 2012 and January 2022. Patients meeting inclusion criteria (age 18–85, Child-Pugh A/B, ASA I–III) and without preexisting biliary disease will be grouped by whether the Pringle maneuver (hepatic inflow occlusion) was used. Investigators will compare the subsequent incidence of postoperative gallbladder diseases such as cholelithiasis and chronic cholecystitis between groups, adjusting for relevant clinical and operative covariates. The analysis aims to clarify whether ischemic insult from the maneuver is associated with increased gallbladder morbidity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged 18 to 85 years.
* Definitive diagnosis of hepatic solid lesions confirmed by imaging (such as CT, MRI, or ultrasound) and/or pathology.
* Underwent elective hepatectomy with gallbladder preservation.
* Preoperative liver function evaluated as Child-Pugh class A or B.
* Preoperative American Society of Anesthesiologists (ASA) physical status classification of I, II, or III.

Exclusion Criteria:

* Preoperative evaluation indicating pre-existing biliary tract diseases (e.g., cholelithiasis, biliary inflammation, neoplastic lesions).
* History of previous upper abdominal surgery.
* Application of non-hepatic inflow occlusion methods during surgery (e.g., hemihepatic vascular occlusion, selective segmental vascular occlusion).
* Personal history of long-term use of hormone replacement therapy, somatostatin and its analogues, or oral contraceptives.
* Loss to follow-up or missing critical data postoperatively.

Where it's running

• The First Affiliated Hospital of University of Science and Technology of China
  Hefei, Anhui, China Recruiting
• Xinqiao Hospital of Army Medical Universit
  Chongqing, Chongqing Municipality, China Recruiting
• Sun Yat-sen University Cancer Center
  Guangzhou, Guangdong, China Recruiting
• Zhujiang Hospital of Southern Medical University
  Guangzhou, Guangdong, China Recruiting
• The First Affiliated Hospital of Harbin Medical University
  Harbin, Heilongjiang, China Recruiting
• Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Jiwei Huang
• Email: huangjiwei@wchscu.cn
• Phone: +86 18980606725

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Electrosurgical Patterns and Learning Curve in Laparoscopic Gallbladder Surgery

  This study observes how surgeon experience relates to patterns of electrosurgery use during elective laparoscopic gallbladder removal to see if experience affects intraoperative difficulty.

  Recruiting University Hospital of Split · Split, Split-Dalmatia County · NCT07888491

• Improvised retrieval bag vs direct gallbladder extraction in laparoscopic cholecystectomy

  This trial tests whether using an improvised retrieval bag to remove the gallbladder during laparoscopic cholecystectomy is as safe and effective as removing it directly without a bag in adults with gallbladder stones.

  Recruiting Rawal Institute of Health Sciences Islamabad · Islamabad, Federal · NCT07823803

• Time to Lose Consciousness With Remimazolam vs Propofol for Anesthetic Induction

  This study tests whether remimazolam changes the time to loss of consciousness compared with propofol for anesthesia induction in adults undergoing elective laparoscopic gallbladder removal.

  Recruiting Phase 4 Universidade Federal de Sergipe · Aracaju, Sergipe · NCT07717684

• Camera-based non-contact vital sign monitoring during surgery

  This project will try a camera-based non-contact system to measure heart rate, blood pressure, and oxygen levels in adults having surgery under general anesthesia.

  Recruiting Taipei Veterans General Hospital, Taiwan · Taipei · NCT07473687

• Keeping a pain diary after laparoscopic gallbladder removal

  This project will see if asking adults having elective laparoscopic gallbladder removal to keep a short pain diary helps track their early postoperative pain better than routine checks.

  Recruiting Muğla Sıtkı Koçman University · Muğla, Menteşe · NCT07308730

• Supraglottic oxygen delivery through an endotracheal tube for ERCP under deep sedation

  This tests whether delivering oxygen just above the vocal cords through an endotracheal tube can prevent low oxygen levels in adults having ERCP with deep sedation.

  Recruiting Phase 2 Zhejiang University · Hangzhou, Zhejiang · NCT07051980

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.