Therapy for LGBTQ adults and their nonaccepting parents

Affirmative Family and Individual Psychotherapy for Sexual and Gender Minority Adults and Their Nonaccepting Parents

Phase 3 Interventional Yale University · NCT05766592

This study is testing whether online therapy for LGBTQ adults with nonaccepting parents can help reduce feelings of depression and anxiety.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment124 (estimated)
Ages20 Years and up
SexAll
SponsorYale University Academic / other
Locations2 sites (New York, New York and 1 other locations)
Trial IDNCT05766592 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of LGBTQ-affirmative cognitive behavioral therapy (CBT) and attachment-based family therapy (ABFT-SGM) delivered via telehealth to sexual and gender minority adults with nonaccepting parents. Participants will engage in 16 weekly therapy sessions, and the study aims to measure reductions in depressive and anxiety symptoms while exploring the mechanisms behind these changes. The research will also investigate whether the type of therapy is more beneficial based on the level of parental acceptance or rejection experienced by the participants.

Who should consider this trial

Good fit: Ideal candidates are sexual and gender minority adults aged 20 and older who experience elevated depressive or anxiety symptoms and have nonaccepting parents willing to participate.

Not a fit: Patients currently receiving frequent mental health treatment or those with active psychosis or suicidality may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly improve mental health outcomes for LGBTQ individuals facing familial rejection.

How similar studies have performed: Previous studies have shown promise in using affirmative therapy approaches for LGBTQ populations, suggesting potential success for this intervention.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* be 20 and older
* be fluent in English
* self-identify as lesbian, bisexual, queer, pansexual, or other non-heterosexual identity
* currently experience elevated depressive or anxiety symptoms (screened initially using a cutoff of ≥ 2.5 on the Brief Symptom Inventory-4 and further confirmed by the BDI and BAI).
* report at least moderate levels of parental rejection or low levels of parental acceptance, as measured using the PARSOS.
* have at least one rejecting/nonaccepting parent that agrees to participate in the therapy.
* live in New York State, Pennsylvania, Connecticut, or Israel.

Exclusion Criteria:

* report current mental health treatment ≥1 day/month (except for medication management ≤1 day/week)
* report beginning a new medication within the past 30 days
* exhibit active psychosis or active mania, as assessed by the SCID-Psych Screen.
* exhibit active suicidality or active homicidality, as assessed by the SIDAS
* be currently legally mandated to attend treatment
* demonstrate gross cognitive impairment, as assessed with the Telephone Interview for Cognitive Status
* do not have a parent willing to participate

Where this trial is running

New York, New York and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Mental Health IssueParent-Child RelationsLGBTQCognitive Behavioral TherapyAttachment-Based Family Therapy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.