Therapeutic yoga program for fatigue in Chronic Fatigue Syndrome and Long Covid patients

Effectiveness of a Therapeutic Yoga and Interoception Program vs Traditional Exercise on Fatigue and Related Variables in Patients With Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME) or Post Covid Syndrome (PCS)

NA · University of Seville · NCT06978582

This study is testing if a special yoga and breathing program can help people with Chronic Fatigue Syndrome or Long Covid feel less tired compared to regular exercise and usual care.

Quick facts

PhaseNA
Study typeInterventional
Enrollment147 (estimated)
Ages18 Years to 70 Years
SexAll
SponsorUniversity of Seville (other)
Locations1 site (Sevilla)
Trial IDNCT06978582 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of a therapeutic conscious movement program, which includes yoga and breathing exercises, compared to conventional low-intensity exercise and usual medical care for patients with Chronic Fatigue Syndrome or Long Covid. Participants will be randomly assigned to one of three groups and will engage in remote sessions delivered via Telehealth over a 12-week period. The study aims to assess changes in fatigue levels, heart rate variability, and other related health outcomes. Participants will also have access to a supportive WhatsApp group and complete digital daily logs to track their progress.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 70 diagnosed with Chronic Fatigue Syndrome or Post-Covid Syndrome who can participate in remote sessions.

Not a fit: Patients with comorbid conditions that could explain their symptoms or those who do not speak Spanish may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly reduce fatigue and improve quality of life for patients suffering from Chronic Fatigue Syndrome and Long Covid.

How similar studies have performed: Other studies have shown promising results with mind-body therapies for fatigue management, but this specific approach is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants must be over 18 and under 70 years of age (to minimize the presence of comorbidities).
* Participants must meet the latest established diagnostic criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post-Covid Syndrome, respectively.
* Participants must have access to a computer, tablet, or mobile device with an internet connection to attend videoconference sessions.
* Participants must have a mobile device compatible with the applications Cardiio: Heart Rate Monitor and Welltory, which will be used to measure heart rate (HR) and heart rate variability (HRV), respectively.
* Participants must be able to remain seated in a chair for at least 45 continuous minutes.
* Participants must have fluent comprehension of the Spanish language.
* Any comorbid condition that could explain the symptomatology associated with the syndrome (such as post-infectious organ damage, heart disease, neurological disorders, cancer, severe psychiatric illness, or metabolic syndrome) must have been ruled out by a physician.

Exclusion Criteria:

* Recent suspicion of comorbid conditions that could explain the syndrome's associated symptoms, not yet ruled out by a qualified healthcare professional.
* Inability to use basic software required for participation in the study (e.g., Microsoft Teams, completing a Google Forms questionnaire).
* Unwillingness to make minor adjustments to daily habits.

Where this trial is running

Sevilla

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Chronic Fatigue Syndrome/ Myalgic Encephalitis, Post COVID Syndrome, exercise movement techniques, Chronic Fatigue Syndrome, mind-body therapies, exercise, pacing

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.