Testing TORL-1-23 in patients with advanced cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This first-in-human study evaluates the safety, tolerability, pharmacokinetics, and antitumor activity of a new treatment called TORL-1-23 in patients with advanced solid tumors, including ovarian cancer, endometrial cancer, and non-small cell lung cancer (NSCLC). Participants must have measurable disease and adequate organ function, and they will be monitored for any adverse effects and treatment efficacy. The study aims to gather crucial data on how this new therapy performs in a clinical setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Advanced solid tumor
* Measurable disease, per RECIST v1.1
* Eastern Cooperative Oncology Group (ECOG) performance status 0-1
* Adequate organ function

Exclusion Criteria:

* Has not recovered \[recovery is defined as NCI CTCAE, version 5.0, grade ≤1\] from the acute toxicities of previous therapy, except treatment-related alopecia or laboratory abnormalities otherwise meeting eligibility requirements
* Received prior chemotherapeutic, investigational, or other therapies for the treatment of cancer within 14 days with small molecule and within 28 days with biologic before the first dose of TORL-1-23
* Progressive or symptomatic brain metastases
* Serious, uncontrolled medical disorder, nonmalignant systemic disease, or active, uncontrolled infection
* History of significant cardiac disease
* History of myelodysplastic syndrome (MDS) or AML
* History of another cancer within 3 years before Day 1 of study treatment, with the exception of basal or squamous cell carcinoma of the skin that has been definitively treated. A history of other malignancies with a low risk of recurrence, including appropriately treated ductal carcinoma in situ (DCIS) of the breast and prostate cancer with a Gleason score less than or equal to 6, are also not excluded
* If female, is pregnant or breastfeeding

Where it's running

• Providence Medical Foundation
  Fullerton, California, United States Recruiting
• UCLA - JCCC Clinical Research Unit
  Los Angeles, California, United States Recruiting
• University of Kentucky Medical Center
  Lexington, Kentucky, United States Recruiting
• University of Minnesota
  Minneapolis, Minnesota, United States Recruiting
• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting
• Memorial Sloan Kettering Cancer Center
  New York, New York, United States Recruiting

Study contacts

• Study coordinator: Nora Ku, MD
• Email: nora.ku@torlbio.com
• Phone: 310-348-9636

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.